Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 3/20 | 0.69 |
| ▸ | HTR2C | P28335 | 6/20 | 0.62 |
| ▸ | HTR2B | P41595 | 6/20 | 0.62 |
| ▸ | STING1 | Q86WV6 | 1/20 | 0.60 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.59 |
| ▸ | KDR | P35968 | 4/20 | 0.56 |
| ▸ | MAP3K20 | Q9NYL2 | 2/20 | 0.56 |
| ▸ | RAF1 | P04049 | 1/20 | 0.56 |
| ▸ | LCK | P06239 | 1/20 | 0.56 |
| ▸ | RET | P07949 | 1/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.56 |
| ▸ | KIT | P10721 | 1/20 | 0.56 |
| ▸ | RIPK3 | Q9Y572 | 1/20 | 0.56 |
| ▸ | NPC1 | O15118 | 1/20 | 0.56 |
| ▸ | RAB9A | P51151 | 1/20 | 0.56 |
| ▸ | BRAF | P15056 | 1/20 | 0.54 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.54 |
| ▸ | TNNI3K | Q59H18 | 1/20 | 0.54 |
| ▸ | P2RY1 | P47900 | 3/20 | 0.53 |
| ▸ | P2RY14 | Q15391 | 2/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7370903 | 0.84 | HTR2C (0.70) | IGF1RHTR2CHTR2BKDRNPC1 | |
| SCHEMBL7447703 | 0.82 | HTR2C (0.71) | HTR2CHTR2BKDRMAP3K20NPC1 | |
| SCHEMBL3807061 | 0.82 | HTR2C (0.73) | HTR2CHTR2BKDRMAP3K20GSK3A | |
| SCHEMBL7375363 | 0.81 | HTR2C (0.72) | IGF1RHTR2CHTR2BKDRMAP3K20 | |
| SCHEMBL27579461 | 0.80 | PLK4 (0.73) | HTR2CHTR2BKDRMAP3K20GSK3A | |
| Hydrochloric Acid SCHEMBL7656134 | 0.80 | HTR2C (0.71) | IGF1RHTR2CHTR2BKDRMAP3K20 | |
| SCHEMBL3158413 | 0.80 | P2RY1 (0.71) | P2RY1P2RY14P2RY2 | |
| SCHEMBL7369937 | 0.80 | HTR2C (0.70) | IGF1RHTR2CHTR2BSTING1KDR | |
| SCHEMBL7373725 | 0.79 | HTR2C (0.74) | HTR2CHTR2BSTING1KDRMAP3K20 | |
| Hydrochloric Acid SCHEMBL7658380 | 0.79 | HTR2C (0.69) | HTR2CHTR2BKDRMAP3K20NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6410529-B1 | DIETETICS; NON-INSULIN DEPENDENT DIABETES; SLEEP DISORDERS | SMITHKLINE BEECHAM P.L.C. (GB) | 2002-06-25 | — | — | US | claimed |
| US-6410529-B1 | DIETETICS; NON-INSULIN DEPENDENT DIABETES; SLEEP DISORDERS | SMITHKLINE BEECHAM P.L.C. (GB) | 2002-06-25 | — | — | US | disclosed |
| EP-1003737-A1 | PHENYL UREA AND PHENYL THIOUREA DERIVATIVES AS HFGAN72 ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 2000-05-31 | — | — | EP | disclosed |
| WO-1999009024-A1 | PHENYL UREA AND PHENYL THIOUREA DERIVATIVES AS HFGAN72 ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1999-02-25 | — | — | WO | disclosed |