Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 7/20 | 0.70 |
| ▸ | HTR2B | P41595 | 7/20 | 0.70 |
| ▸ | IGF1R | P08069 | 1/20 | 0.67 |
| ▸ | HTT | P42858 | 1/20 | 0.66 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.61 |
| ▸ | RAB9A | P51151 | 5/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.59 |
| ▸ | NPC1 | O15118 | 4/20 | 0.59 |
| ▸ | MAPT | P10636 | 3/20 | 0.59 |
| ▸ | TP53 | P04637 | 2/20 | 0.59 |
| ▸ | MEN1 | O00255 | 1/20 | 0.59 |
| ▸ | POLB | P06746 | 1/20 | 0.59 |
| ▸ | TSHR | P16473 | 1/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.59 |
| ▸ | GSK3A | P49840 | 1/20 | 0.57 |
| ▸ | GSK3B | P49841 | 1/20 | 0.57 |
| ▸ | RECQL | P46063 | 1/20 | 0.57 |
| ▸ | PKM | P14618 | 1/20 | 0.56 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.56 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7447703 | 0.88 | HTR2C (0.71) | HTR2CHTR2BRAB9ASMN1; SMN2NPC1 | |
| Hydrochloric Acid SCHEMBL7655749 | 0.88 | HTR2C (0.65) | HTR2CHTR2BIGF1RHTTPDGFRA | |
| SCHEMBL7447310 | 0.86 | HTR2C (0.67) | HTR2CHTR2BHTTPDGFRARAB9A | |
| SCHEMBL3807061 | 0.85 | HTR2C (0.73) | HTR2CHTR2BMAPTGSK3AGSK3B | |
| SCHEMBL7659932 | 0.84 | HTR2C (0.67) | HTR2CHTR2BIGF1RSMN1; SMN2MAPT | |
| SCHEMBL7375771 | 0.84 | HTR2C (0.81) | HTR2CHTR2BIGF1RPDGFRARAB9A | |
| SCHEMBL7451973 | 0.84 | IGF1R (0.69) | HTR2CHTR2BIGF1RRAB9ANPC1 | |
| Dimethylamine SCHEMBL7660199 | 0.84 | HTR2C (0.72) | HTR2CHTR2BMAPTMEN1KMT2A | |
| SCHEMBL27579461 | 0.83 | PLK4 (0.73) | HTR2CHTR2BHTTSMN1; SMN2MEN1 | |
| SCHEMBL7666349 | 0.83 | PDGFRA (0.62) | HTR2CHTR2BIGF1RPDGFRARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6410529-B1 | DIETETICS; NON-INSULIN DEPENDENT DIABETES; SLEEP DISORDERS | SMITHKLINE BEECHAM P.L.C. (GB) | 2002-06-25 | — | — | US | claimed |
| US-6410529-B1 | DIETETICS; NON-INSULIN DEPENDENT DIABETES; SLEEP DISORDERS | SMITHKLINE BEECHAM P.L.C. (GB) | 2002-06-25 | — | — | US | disclosed |
| EP-1003737-A1 | PHENYL UREA AND PHENYL THIOUREA DERIVATIVES AS HFGAN72 ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 2000-05-31 | — | — | EP | disclosed |
| WO-1999009024-A1 | PHENYL UREA AND PHENYL THIOUREA DERIVATIVES AS HFGAN72 ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1999-02-25 | — | — | WO | disclosed |