SCHEMBL7452152

SCHEMBL7452152

O=C1NC(=O)C(Cc2ccc(OCCc3nc(-c4ccccc4)oc3CBr)cc2)S1

nearest known ligand 0.53

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
FFAR1 O14842 9/20 0.53
PPARG P37231 13/20 0.51
PPARA Q07869 5/20 0.50
CYP3A4 P08684 1/20 0.49
RXRA P19793 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10365768 0.92 FFAR1 (0.54) FFAR1PPARGPPARACYP3A4RXRA
SCHEMBL4283015 0.87 PPARG (0.63) PPARGPPARACYP3A4
SCHEMBL170065 0.87 PPARG (0.63) PPARGPPARACYP3A4
SCHEMBL8461494 0.85 FFAR1 (0.60) FFAR1PPARGPPARA
SCHEMBL7452156 0.84 PPARG (0.49) PPARGPPARACYP3A4
SCHEMBL6531845 0.81 PPARG (0.61) FFAR1PPARGPPARA
SCHEMBL10367689 0.79 PPARG (0.60) PPARGPPARACYP3A4
SCHEMBL6960213 0.79 PPARG (0.59) PPARGPPARA
SCHEMBL6968221 0.78 PPARG (0.57) FFAR1PPARGPPARARXRA
SCHEMBL9827679 0.78 PPARG (0.57) FFAR1PPARGPPARACYP3A4RXRA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2575455-A2 METHODS AND COMPOSITIONS FOR TREATING A SUBJECT FOR CENTRAL NERVOUS SYSTEM (CNS) INJURY The Regents of the University of California (US) 2013-04-10 EP disclosed
WO-2011153377-A2 METHODS AND COMPOSITIONS FOR TREATING A SUBJECT FOR CENTRAL NERVOUS SYSTEM (CNS) INJURY THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2011-12-08 WO disclosed
EP-0804193-A4 THIAZOLIDINE DERIVATIVES FOR THE TREATMENT OF PSORIASIS KURTZ THEODORE W (US) 2002-03-27 EP disclosed
US-6110951-A LOWERING INSULIN DRUG THERAPY IN NON-OBESE, NON-DIABETIC INDIVIDUALS BETHESDA PHARMACEUTICALS, INC. 2000-08-29 US disclosed
EP-0804193-A1 THIAZOLIDINE DERIVATIVES FOR THE TREATMENT OF PSORIASIS THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 1997-11-05 EP disclosed
US-5594015-A Thiazolidine derivatives for the treatment of psoriasis REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 1997-01-14 US disclosed
WO-1995035108-A1 THIAZOLIDINE DERIVATIVES FOR THE TREATMENT OF PSORIASIS THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 1995-12-28 WO disclosed
US-5053420-A Antidiabetic agents KURTZ, THEODORE W. 1991-10-01 US disclosed
WO-1991005538-A2 THIAZOLIDINE DERIVATIVES FOR THE TREATMENT OF HYPERTENSION PERSHADSINGH HARRIHAR A (US) 1991-05-02 WO disclosed
EP-0177353-B1 THIAZOLIDINEDIONE DERIVATIVES, THEIR PRODUCTION AND USE Takeda Chemical Industries, Ltd. (JP) 1990-04-11 EP disclosed
US-4725610-A TREATMENT OF HYPERLIPEMIA AND DIABETES TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1988-02-16 US disclosed
EP-0177353-A2 Thiazolidinedione derivatives, their production and use Takeda Chemical Industries, Ltd. (JP) 1986-04-09 EP disclosed