Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR1 | P25103 | 4/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | GPBAR1 | Q8TDU6 | 8/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | DHODH | Q02127 | 1/20 | 0.36 |
| ▸ | HSD17B1 | P14061 | 3/20 | 0.36 |
| ▸ | HSD17B2 | P37059 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8574194 | 0.82 | TACR1 (0.43) | TACR1MEN1KMT2ASMN1; SMN2GPBAR1 | |
| SCHEMBL8572450 | 0.78 | TACR1 (0.44) | TACR1MEN1KMT2ASMN1; SMN2GPBAR1 | |
| SCHEMBL8572769 | 0.76 | TACR1 (0.45) | TACR1MEN1KMT2ASMN1; SMN2GPBAR1 | |
| SCHEMBL8572561 | 0.76 | TACR1 (0.45) | TACR1MEN1KMT2ASMN1; SMN2GPBAR1 | |
| SCHEMBL5883327 | 0.74 | TACR1 (0.54) | TACR1MEN1KMT2ASMN1; SMN2GPBAR1 | |
| SCHEMBL8571115 | 0.74 | PDE4D (0.53) | MEN1KMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL8569426 | 0.73 | TACR1 (0.42) | TACR1MEN1KMT2ASMN1; SMN2GPBAR1 | |
| SCHEMBL8572527 | 0.73 | TACR1 (0.48) | TACR1MEN1KMT2ASMN1; SMN2GPBAR1 | |
| Hydrochloric Acid SCHEMBL5883686 | 0.73 | TACR1 (0.52) | TACR1MEN1KMT2ASMN1; SMN2GPBAR1 | |
| SCHEMBL8568184 | 0.72 | TACR1 (0.59) | TACR1GPBAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0921800-A4 | SUBSTITUTED BIPHENYL ISOXAZOLE SULFONAMIDES | BRISTOL MYERS SQUIBB CO (US) | 2000-12-06 | — | — | EP | claimed |
| EP-0921800-A1 | SUBSTITUTED BIPHENYL ISOXAZOLE SULFONAMIDES | BRISTOL-MYERS SQUIBB COMPANY (US) | 1999-06-16 | — | — | EP | claimed |
| WO-1997029748-A1 | SUBSTITUTED BIPHENYL ISOXAZOLE SULFONAMIDES | BRISTOL-MYERS SQUIBB COMPANY (US) | 1997-08-21 | — | — | WO | claimed |