Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 15/20 | 0.48 |
| ▸ | KLK1 | P06870 | 4/20 | 0.47 |
| ▸ | KLK5 | Q9Y337 | 4/20 | 0.47 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.41 |
| ▸ | F10 | P00742 | 1/20 | 0.41 |
| ▸ | PLG | P00747 | 1/20 | 0.41 |
| ▸ | PLAT | P00750 | 1/20 | 0.41 |
| ▸ | PROC | P04070 | 1/20 | 0.41 |
| ▸ | HPN | P05981 | 1/20 | 0.41 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.41 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.41 |
| ▸ | NQO2 | P16083 | 1/20 | 0.41 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.41 |
| ▸ | SLC47A2 | Q86VL8 | 1/20 | 0.41 |
| ▸ | SLC47A1 | Q96FL8 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7445168 | 0.97 | F2 (0.51) | F2KLK1KLK5SLC22A2F10 | |
| Hydrochloric Acid SCHEMBL7449253 | 0.96 | F2 (0.50) | F2KLK1KLK5SLC22A2F10 | |
| SCHEMBL7446295 | 0.95 | KLK1 (0.44) | F2KLK1KLK5SLC22A2F10 | |
| Hydrochloric Acid SCHEMBL7442296 | 0.95 | F2 (0.44) | F2KLK1KLK5SLC22A2F10 | |
| Hydrochloric Acid SCHEMBL7449067 | 0.94 | KLK1 (0.45) | F2KLK1KLK5SLC22A2F10 | |
| SCHEMBL7446576 | 0.93 | F2 (0.52) | F2KLK1KLK5 | |
| SCHEMBL7449323 | 0.93 | F2 (0.49) | F2KLK1KLK5 | |
| SCHEMBL7448557 | 0.92 | F2 (0.42) | F2KLK1KLK5SLC22A2F10 | |
| Hydrochloric Acid SCHEMBL7161775 | 0.92 | NQO2 (0.45) | F2KLK1KLK5NQO2NPC1 | |
| Hydrochloric Acid SCHEMBL7453316 | 0.92 | KLK1 (0.47) | F2KLK1KLK5NPC1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-3343359-B2 | — | — | 2002-11-11 | — | — | JP | claimed |
| JP-2001509815-A | — | — | 2001-07-24 | — | — | JP | claimed |
| EP-0966454-A1 | DISUBSTITUTED BICYCLIC HETEROCYCLES, THEIR PRODUCTION AND USE AS MEDICAMENTS | Boehringer Ingelheim Pharma KG (DE) | 1999-12-29 | — | — | EP | claimed |
| WO-1998037075-A1 | DISUBSTITUTED BICYCLIC HETEROCYCLES, THEIR PRODUCTION AND USE AS MEDICAMENTS | BOEHRINGER INGELHEIM PHARMA KG (DE) | 1998-08-27 | — | — | WO | claimed |
| EP-0966454-A1 | DISUBSTITUTED BICYCLIC HETEROCYCLES, THEIR PRODUCTION AND USE AS MEDICAMENTS | Boehringer Ingelheim Pharma KG (DE) | 1999-12-29 | — | — | EP | disclosed |
| WO-1998037075-A1 | DISUBSTITUTED BICYCLIC HETEROCYCLES, THEIR PRODUCTION AND USE AS MEDICAMENTS | BOEHRINGER INGELHEIM PHARMA KG (DE) | 1998-08-27 | — | — | WO | disclosed |