Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 11/20 | 0.66 |
| ▸ | F10 | P00742 | 1/20 | 0.53 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.53 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.50 |
| ▸ | PRSS1 | P07477 | 4/20 | 0.48 |
| ▸ | PLG | P00747 | 1/20 | 0.48 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.48 |
| ▸ | C1S | P09871 | 1/20 | 0.48 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.48 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7453459 | 0.88 | F2 (0.62) | F2F10NR4A2MRGPRX4PRSS1 | |
| SCHEMBL7718664 | 0.88 | F2 (0.65) | F2F10NR4A2MRGPRX4PRSS1 | |
| SCHEMBL7454069 | 0.87 | F2 (0.70) | F2F10NR4A2MRGPRX4PRSS1 | |
| SCHEMBL7450278 | 0.83 | F2 (0.72) | F2F10NR4A2PRSS1 | |
| SCHEMBL7452930 | 0.83 | F2 (0.94) | F2F10NR4A2PRSS1 | |
| SCHEMBL7719450 | 0.83 | F2 (0.61) | F2F10NR4A2PRSS1NR1H4 | |
| SCHEMBL7670816 | 0.82 | F10 (0.67) | F2F10NR4A2MRGPRX4PRSS1 | |
| SCHEMBL7660470 | 0.82 | F2 (0.63) | F2F10NR4A2MRGPRX4NR1H4 | |
| SCHEMBL7719048 | 0.82 | F2 (0.66) | F2F10NR4A2MRGPRX4PRSS1 | |
| SCHEMBL7455175 | 0.80 | F2 (0.84) | F2F10MRGPRX4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1214291-A1 | BIPHENYL DERIVATIVES USED AS NHE-3 INHIBITORS | MERCK PATENT GmbH (DE) | 2002-06-19 | — | — | EP | claimed |
| WO-2001021582-A1 | BIPHENYL DERIVATIVES USED AS NHE-3 INHIBITORS | MERCK PATENT GMBH (DE) | 2001-03-29 | — | — | WO | claimed |
| EP-1076643-A1 | BIPHENYL DERIVATIVES | MERCK PATENT GmbH (DE) | 2001-02-21 | — | — | EP | claimed |
| WO-1999057096-A1 | BIPHENYL DERIVATIVES | MERCK PATENT GMBH (DE) | 1999-11-11 | — | — | WO | claimed |
| EP-1214291-A1 | BIPHENYL DERIVATIVES USED AS NHE-3 INHIBITORS | MERCK PATENT GmbH (DE) | 2002-06-19 | — | — | EP | disclosed |
| WO-2001021582-A1 | BIPHENYL DERIVATIVES USED AS NHE-3 INHIBITORS | MERCK PATENT GMBH (DE) | 2001-03-29 | — | — | WO | disclosed |
| EP-1076643-A1 | BIPHENYL DERIVATIVES | MERCK PATENT GmbH (DE) | 2001-02-21 | — | — | EP | disclosed |
| WO-1999057096-A1 | BIPHENYL DERIVATIVES | MERCK PATENT GMBH (DE) | 1999-11-11 | — | — | WO | disclosed |