SCHEMBL745451 — predicted protein targets

Predicted protein targets (top 9)

	gene	UniProt	supporting neighbours	confidence
▸	CLPP	Q16740	15/20	0.50

▸	POLB	P06746	2/20	0.45

▸	NPC1	O15118	1/20	0.45

▸	TP53	P04637	1/20	0.45

▸	RAB9A	P51151	1/20	0.45

▸	L3MBTL1	Q9Y468	1/20	0.43

▸	CYP3A4	P08684	2/20	0.43

▸	HPGD	P15428	1/20	0.43

▸	CYP2C19	P33261	1/20	0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL12037721	0.96	CLPP (0.51)	CLPPPOLBNPC1TP53RAB9A
SCHEMBL745441	0.94	POLB (0.46)	CLPPPOLBNPC1TP53RAB9A
SCHEMBL763063	0.92	CLPP (0.52)	CLPPPOLBNPC1TP53RAB9A
SCHEMBL10225230	0.92	CLPP (0.48)	CLPPPOLBNPC1TP53RAB9A
SCHEMBL13184826	0.90	POLB (0.47)	CLPPPOLBNPC1TP53RAB9A
SCHEMBL747045	0.89	CLPP (0.45)	CLPPPOLBNPC1TP53RAB9A
SCHEMBL747072	0.88	POLB (0.46)	POLBNPC1TP53RAB9AL3MBTL1
SCHEMBL748454	0.88	POLB (0.46)	POLBNPC1TP53RAB9AL3MBTL1
SCHEMBL748483	0.88	CYP3A4 (0.48)	POLBNPC1TP53RAB9ACYP3A4
SCHEMBL749491	0.86	POLB (0.45)	POLBNPC1TP53RAB9AL3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
US-8138337-B2	Reverse-turn mimetics and method relating thereto	CHOONGWAE PHARMA CORPORATION (KR)	2012-03-20	—	—	US	disclosed