Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 5/20 | 0.52 |
| ▸ | SMARCA2 | P51531 | 4/20 | 0.42 |
| ▸ | SMARCA4 | P51532 | 4/20 | 0.42 |
| ▸ | NPC1 | O15118 | 3/20 | 0.36 |
| ▸ | RAB9A | P51151 | 3/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HBB | P68871 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.36 |
| ▸ | CASP3 | P42574 | 1/20 | 0.36 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.36 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.36 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | PPARG | P37231 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7447799 | 0.93 | GRM5 (0.44) | GRM5SMARCA2SMARCA4NPC1RAB9A | |
| SCHEMBL7446764 | 0.93 | GRM5 (0.52) | GRM5SMARCA2SMARCA4NPC1RAB9A | |
| SCHEMBL7451341 | 0.90 | GRM5 (0.53) | GRM5SMARCA2SMARCA4NPC1RAB9A | |
| SCHEMBL7451577 | 0.86 | GRM5 (0.55) | GRM5SMARCA2SMARCA4NPC1RAB9A | |
| SCHEMBL7456653 | 0.86 | GRM5 (0.44) | GRM5SMARCA2SMARCA4NPC1RAB9A | |
| SCHEMBL7451159 | 0.85 | GRM5 (0.60) | GRM5SMARCA2SMARCA4GRM1GRM4 | |
| SCHEMBL7454299 | 0.83 | GRM5 (0.69) | GRM5SMARCA2SMARCA4NPC1RAB9A | |
| SCHEMBL7454651 | 0.81 | GRM5 (0.52) | GRM5SMARCA2SMARCA4NPC1RAB9A | |
| SCHEMBL7453851 | 0.81 | GRM5 (0.69) | GRM5SMARCA2SMARCA4NPC1RAB9A | |
| SCHEMBL7449902 | 0.81 | GRM5 (0.46) | GRM5SMARCA2SMARCA4NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011151361-A1 | NOVEL COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2011-12-08 | — | — | WO | claimed |
| WO-2011151361-A1 | NOVEL COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2011-12-08 | — | — | WO | disclosed |
| WO-2011151361-A1 | NOVEL COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2011-12-08 | — | — | WO | disclosed |