Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 6/20 | 0.44 |
| ▸ | SORT1 | Q99523 | 2/20 | 0.42 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.41 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 3/20 | 0.37 |
| ▸ | RAB9A | P51151 | 3/20 | 0.37 |
| ▸ | F10 | P00742 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | HBB | P68871 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | ATR | Q13535 | 1/20 | 0.36 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.36 |
| ▸ | CASP3 | P42574 | 1/20 | 0.36 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7454850 | 0.93 | GRM5 (0.52) | GRM5SORT1SMARCA2SMARCA4NPC1 | |
| SCHEMBL7456653 | 0.92 | GRM5 (0.44) | GRM5SORT1SMARCA2SMARCA4NPC1 | |
| SCHEMBL7449902 | 0.87 | GRM5 (0.46) | GRM5SORT1SMARCA2SMARCA4NPC1 | |
| SCHEMBL7446764 | 0.86 | GRM5 (0.52) | GRM5SORT1SMARCA2SMARCA4NPC1 | |
| SCHEMBL7453711 | 0.83 | GRM5 (0.58) | GRM5SORT1SMARCA2SMARCA4NPC1 | |
| SCHEMBL7458050 | 0.83 | GRM5 (0.48) | GRM5SORT1SMARCA2SMARCA4MEN1 | |
| SCHEMBL7451341 | 0.83 | GRM5 (0.53) | GRM5SORT1SMARCA2SMARCA4NPC1 | |
| SCHEMBL12067755 | 0.82 | GRM5 (0.43) | GRM5SORT1SMARCA2SMARCA4NPC1 | |
| SCHEMBL12067837 | 0.81 | GRM5 (0.43) | GRM5SORT1SMARCA2SMARCA4NPC1 | |
| SCHEMBL12067831 | 0.80 | L3MBTL1 (0.45) | NPC1RAB9AALDH1A1LMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011151361-A1 | NOVEL COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2011-12-08 | — | — | WO | claimed |
| WO-2011151361-A1 | NOVEL COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2011-12-08 | — | — | WO | disclosed |
| WO-2011151361-A1 | NOVEL COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2011-12-08 | — | — | WO | disclosed |