Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 16/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 15/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 9/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.33 |
| ▸ | NOS3 | P29474 | 1/20 | 0.33 |
| ▸ | NOS1 | P29475 | 1/20 | 0.33 |
| ▸ | NOS2 | P35228 | 1/20 | 0.33 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.33 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7455407 | 1.00 | GPR119 (0.36) | GPR119SLC6A4SLC6A2SLC6A3CYP2D6 | |
| SCHEMBL4443673 | 0.80 | RPLP1 (0.34) | SLC6A4SLC6A2SLC6A3CYP2D6KCNH2 | |
| SCHEMBL4442462 | 0.79 | MEN1 (0.36) | SLC6A4SLC6A2SLC6A3CYP2D6CHRM3 | |
| SCHEMBL4437552 | 0.79 | SLC6A2 (0.39) | SLC6A4SLC6A2SLC6A3CYP2D6NOS3 | |
| SCHEMBL4431999 | 0.79 | MEN1 (0.34) | SLC6A4SLC6A2SLC6A3CYP2D6KCNH2 | |
| SCHEMBL4439873 | 0.79 | SLC6A4 (0.36) | SLC6A4SLC6A2SLC6A3CYP2D6CHRM3 | |
| SCHEMBL4436446 | 0.79 | JAK2 (0.37) | GPR119NOS3NOS1NOS2SSTR4 | |
| SCHEMBL4445222 | 0.78 | RPLP1 (0.40) | GPR119KCNH2 | |
| SCHEMBL4433912 | 0.78 | FLT3 (0.35) | GPR119SLC6A4SLC6A2SLC6A3KCNH2 | |
| SCHEMBL4444981 | 0.78 | SLC6A4 (0.40) | SLC6A4SLC6A2SLC6A3CYP2D6NOS3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1196391-A1 | BENZIMIDAZOLONE DERIVATIVES AND THEIR USE AS PHOSPHODIESTERASE INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2002-04-17 | — | — | EP | disclosed |
| WO-2001005770-A1 | BENZIMIDAZOLONE DERIVATIVES AND THEIR USE AS PHOSPHODIESTERASE INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-01-25 | — | — | WO | disclosed |