SCHEMBL745542

SCHEMBL745542

CS(=O)(=O)c1ccc(N2CCC3(CCN(S(=O)(=O)c4ccccc4Cl)CC3)C2)cc1

nearest known ligand 0.52

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
CYP2C9 P11712 11/20 0.52
CYP1A2 P05177 10/20 0.52
CYP3A4 P08684 10/20 0.52
CYP2C19 P33261 9/20 0.52
ALDH1A1 P00352 8/20 0.52
TSHR P16473 4/20 0.52
CYP2D6 P10635 4/20 0.52
USP2 O75604 7/20 0.50
SMN1; SMN2 Q16637 5/20 0.50
HIF1A Q16665 4/20 0.48
CCR1 P32246 1/20 0.47
HSD17B10 Q99714 4/20 0.47
MEN1 O00255 2/20 0.47
KMT2A Q03164 2/20 0.47
MAPK1 P28482 3/20 0.46
CHRM4 P08173 1/20 0.44
KCNJ1 P48048 1/20 0.44
LIPE Q05469 1/20 0.43
HPGD P15428 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL746711 0.85 CYP2C9 (0.48) CYP2C9CYP1A2CYP3A4CYP2C19ALDH1A1
SCHEMBL746534 0.83 CYP3A4 (0.48) CYP2C9CYP1A2CYP3A4CYP2C19ALDH1A1
SCHEMBL744430 0.80 LIPE (0.68) CYP2C9CYP1A2CYP3A4CYP2C19ALDH1A1
SCHEMBL746622 0.79 CCR1 (0.44) CYP2C9CYP1A2CYP3A4CYP2C19ALDH1A1
SCHEMBL746972 0.79 LIPE (0.67) CCR1MAPK1CHRM4KCNJ1LIPE
SCHEMBL744705 0.78 CYP1A2 (0.47) CYP2C9CYP1A2CYP3A4CYP2C19ALDH1A1
SCHEMBL744989 0.78 CYP3A4 (0.57) CYP2C9CYP1A2CYP3A4CYP2C19ALDH1A1
SCHEMBL745718 0.76 CYP2C9 (0.46) CYP2C9CYP1A2CYP3A4CYP2C19ALDH1A1
SCHEMBL744218 0.76 CYP3A4 (0.52) CYP2C9CYP1A2CYP3A4CYP2C19ALDH1A1
SCHEMBL745067 0.76 CCR1 (0.39) CYP2C9CYP1A2CYP3A4CYP2C19ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2430023-A1 AZACYCLIC SPIRODERIVATIVES AS HSL INHIBITORS F. Hoffmann-La Roche AG (CH) 2012-03-21 EP disclosed
WO-2010130665-A1 AZACYCLIC SPIRODERIVATIVES AS HSL INHIBITORS F. HOFFMANN-LA ROCHE AG (CH) 2010-11-18 WO disclosed