SCHEMBL7455482

SCHEMBL7455482

Cc1cc(N(CCO)CCO)cc(-c2cc[nH]c2)c1N

nearest known ligand 0.34

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
MAPT P10636 2/20 0.34
GAA P10253 1/20 0.34
PKM P14618 1/20 0.34
HTT P42858 1/20 0.34
MCL1 Q07820 1/20 0.34
MEN1 O00255 1/20 0.34
NPC1 O15118 1/20 0.34
LMNA P02545 1/20 0.34
POLB P06746 1/20 0.34
MAPK1 P28482 1/20 0.34
MMP14 P50281 1/20 0.34
RAB9A P51151 1/20 0.34
KMT2A Q03164 1/20 0.34
SMN1; SMN2 Q16637 1/20 0.34
TDP1 Q9NUW8 1/20 0.34
L3MBTL1 Q9Y468 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7465818 0.84 KMT2A (0.36) MAPTGAAPKMHTTMCL1
SCHEMBL7466832 0.80 KMT2A (0.33) MAPTGAAPKMHTTMCL1
SCHEMBL7461574 0.78 PIK3CD (0.34) MAPTGAAPKMHTTMCL1
SCHEMBL7459373 0.77 PDE10A (0.30)
SCHEMBL7460463 0.76 CYP2A6 (0.39) MAPTGAAPKMHTTMCL1
SCHEMBL7460434 0.76 ALDH1A1 (0.36) MAPTGAA
SCHEMBL7812329 0.76 MAPT (0.36) MAPTGAAPKMHTTMCL1
SCHEMBL7457559 0.76 MAPT (0.34) MAPTGAAPKMHTTMCL1
SCHEMBL7465045 0.76 ALDH1A1 (0.36) MAPTGAA
SCHEMBL4011860 0.76 MAPT (0.42) MAPTGAAPKMHTTMCL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0963982-B1 New diaminobenzene derivatives and these componends containing colouring agents WELLA AG (DE) 2002-03-13 EP disclosed
US-6132475-A FOR OXIDATION DYEING OF KERATIN FIBERS; INCLUDES COUPLER AND DEVELOPER, IN WHICH THE DEVELOPER IS A SUBSTITUTED 2-(FURYL, THIENYL, PYRROLYL, OR SELENOPHENE) P-DIAMINOBENZENE DERIVATIVE OF GIVEN FORMULA; COLORFASTNESS, WASHFASTNESS WELLA AKTIENGESELLSCHAFT (DE) 2000-10-17 US disclosed
EP-0963982-A2 New diaminobenzene derivatives and these componends containing colouring agents Wella Aktiengesellschaft (DE) 1999-12-15 EP disclosed