Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | ERN1 | O75460 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | MMP14 | P50281 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7455538 | 1.00 | MAPT (0.40) | MAPTALDH1A1ERN1POLBGAA | |
| SCHEMBL16302853 | 0.77 | SMN1; SMN2 (0.46) | MAPTALDH1A1POLBGAAMMP14 | |
| SCHEMBL14764234 | 0.76 | MAPT (0.38) | MAPTALDH1A1ERN1POLBGAA | |
| SCHEMBL2569899 | 0.76 | MAPT (0.38) | MAPTALDH1A1ERN1POLBGAA | |
| SCHEMBL30018808 | 0.76 | MAPT (0.38) | MAPTALDH1A1ERN1POLBGAA | |
| SCHEMBL1997660 | 0.75 | PDE10A (0.45) | MAPTALDH1A1POLBGAARAB9A | |
| SCHEMBL1997663 | 0.75 | PDE10A (0.45) | MAPTALDH1A1POLBGAARAB9A | |
| SCHEMBL4899860 | 0.72 | ALDH1A1 (0.40) | MAPTALDH1A1POLBGAAMMP14 | |
| SCHEMBL4899871 | 0.72 | ALDH1A1 (0.40) | MAPTALDH1A1POLBGAAMMP14 | |
| SCHEMBL4874074 | 0.71 | ALDH1A1 (0.41) | MAPTALDH1A1ERN1GAARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1023308-A4 | INHIBITORS OF NUCLEOSIDE METABOLISM | EINSTEIN COLL MED (US) | 2002-05-29 | — | — | EP | disclosed |
| EP-1023308-A1 | INHIBITORS OF NUCLEOSIDE METABOLISM | ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIVERSITY (US) | 2000-08-02 | — | — | EP | disclosed |
| WO-1999019338-A1 | INHIBITORS OF NUCLEOSIDE METABOLISM | ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIVERSITY (US) | 1999-04-22 | — | — | WO | disclosed |