SCHEMBL7455653

SCHEMBL7455653

CC(C)(C)OC(=O)C=Cc1cnc2c(c1)NC(=O)CO2

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 2/20 0.39
TRPV1 Q8NER1 2/20 0.39
KDM4E B2RXH2 2/20 0.38
KMT2A Q03164 1/20 0.38
SMN1; SMN2 Q16637 1/20 0.38
ALDH1A1 P00352 2/20 0.36
LMNA P02545 2/20 0.36
MGLL Q99685 1/20 0.36
NR3C2 P08235 3/20 0.35
L3MBTL1 Q9Y468 2/20 0.35
CTDSP1 Q9GZU7 1/20 0.35
TDP1 Q9NUW8 1/20 0.35
USP2 O75604 1/20 0.34
DNMT1 P26358 1/20 0.34
HTT P42858 1/20 0.34
NR1I2 O75469 1/20 0.34
PGR P06401 1/20 0.34
CYP3A4 P08684 1/20 0.34
ADORA3 P0DMS8 1/20 0.34
CYP2C9 P11712 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7455647 1.00 MAPT (0.39) MAPTTRPV1KDM4EKMT2ASMN1; SMN2
SCHEMBL3888548 0.82 ALDH1A1 (0.44) MAPTTRPV1KDM4EALDH1A1LMNA
SCHEMBL3888550 0.82 ALDH1A1 (0.44) MAPTTRPV1KDM4EALDH1A1LMNA
SCHEMBL4095661 0.78
SCHEMBL4095665 0.78
SCHEMBL4101515 0.75
SCHEMBL4101511 0.75
SCHEMBL2796664 0.74 NR3C2 (0.41) MAPTKMT2ASMN1; SMN2ALDH1A1LMNA
SCHEMBL1092656 0.74
SCHEMBL12315223 0.74

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6268378-B1 TREATING AND PREVENTING OSTEOPOROSIS, AND INHIBITING VASCULAR RESTENOSIS, DIABETIC RETINOPATHY, MACULAR DEGENERATION, ANGIOGENESIS, ATHEROSCLEROSIS, INFLAMMATION, VIRAL DISEASE, AND TUMOR GROWTH. MERCK & CO., INC. 2001-07-31 US disclosed
CN-1284955-A Integrin receptor antagonists MERCK & CO INC (US) 2001-02-21 CN disclosed
EP-1040111-A1 INTEGRIN RECEPTOR ANTAGONISTS Merck & Co., Inc. (US) 2000-10-04 EP disclosed
US-6066648-A USEFUL IN INHIBITING BONE RESORPTION, TREATING AND PREVENTING OSTEOPOROSIS, AND INHIBITING VASCULAR RESTENOSIS, DIABETIC RETINOPATHY, MACULAR DEGENERATION, ANGIOGENESIS, ATHEROSCLEROSIS, INFLAMMATION, VIRAL DISEASE, AND TUMOR GROWTH MERCK & CO., INC. (US) 2000-05-23 US disclosed
US-6017926-A Integrin receptor antagonists MERCK & CO., INC. (US) 2000-01-25 US disclosed
WO-1999031099-A1 INTEGRIN RECEPTOR ANTAGONISTS MERCK & CO., INC. (US) 1999-06-24 WO disclosed