Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 1/20 | 0.51 |
| ▸ | ITGB3 | P05106 | 3/20 | 0.51 |
| ▸ | ITGAV | P06756 | 3/20 | 0.51 |
| ▸ | ITGA2B | P08514 | 3/20 | 0.51 |
| ▸ | CTSS | P25774 | 5/20 | 0.45 |
| ▸ | CTSL | P07711 | 3/20 | 0.45 |
| ▸ | CTSB | P07858 | 3/20 | 0.45 |
| ▸ | CTSK | P43235 | 5/20 | 0.43 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | KYNU | Q16719 | 1/20 | 0.41 |
| ▸ | PPARA | Q07869 | 1/20 | 0.41 |
| ▸ | TACR1 | P25103 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7456386 | 0.90 | SYK (0.53) | SYKITGB3ITGAVITGA2BCTSS | |
| SCHEMBL7456394 | 0.90 | SYK (0.53) | SYKITGB3ITGAVITGA2BCTSS | |
| SCHEMBL7962795 | 0.88 | SYK (0.51) | SYKITGB3ITGAVITGA2BCTSS | |
| SCHEMBL7962798 | 0.88 | SYK (0.51) | SYKITGB3ITGAVITGA2BCTSS | |
| SCHEMBL6016434 | 0.83 | ITGB3 (0.61) | SYKITGB3ITGAVITGA2BCTSS | |
| SCHEMBL6016196 | 0.83 | ITGB3 (0.46) | SYKITGB3ITGAVITGA2BCTSS | |
| SCHEMBL6016195 | 0.83 | ITGB3 (0.46) | SYKITGB3ITGAVITGA2BCTSS | |
| SCHEMBL7450313 | 0.82 | SYK (0.49) | SYKITGB3ITGAVITGA2BCTSS | |
| SCHEMBL7229962 | 0.82 | ITGB3 (0.51) | SYKITGB3ITGAVITGA2BCTSS | |
| SCHEMBL6016219 | 0.82 | ITGB3 (0.60) | SYKITGB3ITGAVITGA2BCTSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1187825-A1 | THIOPHENE INTEGRIN INHIBITORS | Shire Biochem Inc. (CA) | 2002-03-20 | — | — | EP | disclosed |
| US-6274620-B1 | 2-BENZENESULFONYLAMINO-3-((5-BROMO-THIOPHENE-2-CARBONYL)-AMINO )PROPIONIC ACID-TERT-BUTYL ESTERS AS ANGIOGENESIS INHIBITORS; ANTICARCINOGENIC AGENTS; OSTEOPOROSIS, RESTENOSIS, AND OCULAR NEOVASCULARIZATION | BIOCHEM PHARMA INC. (CA) | 2001-08-14 | — | — | US | disclosed |
| WO-2000075129-A1 | THIOPHENE INTEGRIN INHIBITORS | SHIRE BIOCHEM INC. (CA) | 2000-12-14 | — | — | WO | disclosed |