SCHEMBL745600

SCHEMBL745600

NCc1cncc(Br)c1

nearest known ligand 0.00

⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL28798132 0.98 KDM4E (0.46)
SCHEMBL748040 0.82 TAAR1 (0.50)
SCHEMBL8048996 0.82 LOXL2 (0.46)
Hydrochloric Acid SCHEMBL14157114 0.80 TAAR1 (0.48)
SCHEMBL1419365 0.79 CYP2A6 (0.48)
SCHEMBL3183730 0.78
SCHEMBL9978546 0.77 POLB (0.36)
SCHEMBL1419853 0.77 HRH1 (0.49)
SCHEMBL7672653 0.76
SCHEMBL14157337 0.76

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 514 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-117304095-B N-aryl-N-arpropargyl-aromatic acetamide compound and pharmaceutical application thereof ZHEJIANG UNIVERSITY (CN) 2026-05-26 CN disclosed
US-20260116878-A1 INDAZOLE INHIBITORS OF THE WNT SIGNAL PATHWAY AND THERAPEUTIC USES THEREOF BIOSPLICE THERAPEUTICS INC (US) 2026-04-30 US disclosed
US-20260092045-A1 SUBSTITUTED BENZOFURAN, BENZOPYRROLE, BENZOTHIOPHENE, AND STRUCTURALLY RELATED COMPLEMENT INHIBITORS WILMINGTON TRUST, NATIONAL ASSOCIATION 2026-04-02 US disclosed
EP-4709712-A1 GSK3A INHIBITORS AND METHODS OF USE THEREOF Blueprint Medicines Corporation (US) 2026-03-18 EP disclosed
US-20260034220-A1 ANTI-CEA IMMUNOCONJUGATES, AND USES THEREOF BOLT BIOTHERAPEUTICS, INC. (US) 2026-02-05 US disclosed
US-12492202-B2 Macrocyclic PAD4 inhibitors useful as immunosuppressant BRISTOL-MYERS SQUIBB COMPANY (US) 2025-12-09 US disclosed
EP-4524133-A2 SUBSTITUTED BENZOFURAN, BENZOPYRROLE, BENZOTHIOPHENE, AND STRUCTURALLY RELATED COMPLEMENT INHIBITORS Biocryst Pharmaceuticals, Inc. (US) 2025-03-19 EP disclosed
EP-3653618-B1 NEW DIHYDROQUINOLINE-2-ONE DERIVATIVES HOFFMANN LA ROCHE (CH) 2025-01-08 EP disclosed
WO-2024233900-A1 GSK3A INHIBITORS AND METHODS OF USE THEREOF BLUEPRINT MEDICINES CORPORATION (US) 2024-11-14 WO disclosed
EP-3939658-B1 SUBSTITUTED BENZOPYRROLE AND STRUCTURALLY RELATED COMPLEMENT INHIBITORS BIOCRYST PHARM INC (US) 2024-10-02 EP disclosed
EP-1066287-A1 AZATRICYCLIC COMPOUNDS R.J. REYNOLDS TOBACCO COMPANY (US) 2001-01-10 EP disclosed
US-6057446-A Certain 1-aza-tricyclo [3.3.1-13,7 ] decane compounds TARGACEPT, INC., A CORPORATION OF DELAWARE 2000-05-02 US disclosed
EP-0994875-A1 3-PYRIDYL-1-AZA-BICYCLO-ALKANE DERIVATIVES FOR PREVENTION AND TREATMENT OF CNS DISORDERS R.J. REYNOLDS TOBACCO COMPANY (US) 2000-04-26 EP disclosed
US-5986100-A 1-AZA-2-(3-PYRIDYL)-1-AZATRICYCLO(3.3.1.1 3,7)DECANE NICOTINIC CHOLINERGIC AGENTS TARGACEPT, INC. 1999-11-16 US disclosed
WO-1999051602-A1 AZATRICYCLO[3.3.1.1] DECANE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM R.J. REYNOLDS TOBACCO COMPANY (US) 1999-10-14 WO disclosed
WO-1999051601-A1 AZATRICYCLIC COMPOUNDS R.J. REYNOLDS TOBACCO COMPANY (US) 1999-10-14 WO disclosed
US-5952339-A Pharmaceutical compositions and methods of using nicotinic antagonists for treating a condition or disorder characterized by alteration in normal neurotransmitter release TARGACEPT, INC. 1999-09-14 US disclosed
WO-1999000385-A1 3-PYRIDYL-1-AZA-BICYCLO-ALKANE DERIVATIVES FOR PREVENTION AND TREATMENT OF CNS DISORDERS R.J. REYNOLDS TOBACCO COMPANY (US) 1999-01-07 WO disclosed
WO-1995028400-A1 NOVEL BENZOFUSED 5-MEMBERED HETEROCYCLIC RINGS FOR THE TREATMENT OF MIGRAINE GLAXO GROUP LIMITED (GB) 1995-10-26 WO disclosed
US-5002949-A Anticoagulants AMERICAN HOME PRODUCTS CORPORATION (US) 1991-03-26 US disclosed