Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.33 |
| ▸ | NOS3 | P29474 | 1/20 | 0.33 |
| ▸ | NOS1 | P29475 | 1/20 | 0.33 |
| ▸ | TDO2 | P48775 | 1/20 | 0.32 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.32 |
| ▸ | CCNC | P24863 | 1/20 | 0.32 |
| ▸ | CDK8 | P49336 | 1/20 | 0.32 |
| ▸ | CDK9 | P50750 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.32 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.32 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.31 |
| ▸ | BTK | Q06187 | 1/20 | 0.31 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.30 |
| ▸ | TRPC6 | Q9Y210 | 1/20 | 0.30 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7456680 | 1.00 | EGLN1 (0.33) | EGLN1NOS3NOS1TDO2CCNT1 | |
| SCHEMBL1378923 | 0.93 | SCN9A (0.36) | EGLN1NOS3NOS1TDO2CCNT1 | |
| SCHEMBL1378922 | 0.93 | SCN9A (0.36) | EGLN1NOS3NOS1TDO2CCNT1 | |
| SCHEMBL5203626 | 0.93 | SCN9A (0.36) | EGLN1NOS3NOS1TDO2CCNT1 | |
| SCHEMBL1376059 | 0.93 | MEN1 (0.32) | EGLN1NOS3NOS1TDO2CCNT1 | |
| SCHEMBL1376060 | 0.93 | MEN1 (0.32) | EGLN1NOS3NOS1TDO2CCNT1 | |
| SCHEMBL1376354 | 0.92 | SCN9A (0.36) | EGLN1NOS3NOS1CCNT1CCNC | |
| SCHEMBL1377657 | 0.92 | SCN9A (0.36) | EGLN1NOS3NOS1CCNT1CCNC | |
| SCHEMBL1376355 | 0.92 | SCN9A (0.36) | EGLN1NOS3NOS1CCNT1CCNC | |
| SCHEMBL1375389 | 0.89 | TDO2 (0.36) | EGLN1NOS3NOS1TDO2CCNT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1165523-A1 | NEUROTROPHIC SUBSTITUTED PYRIMIDINES | Krenitsky Pharmaceuticals, Inc. (US) | 2002-01-02 | — | — | EP | disclosed |
| WO-2000061562-A1 | NEUROTROPHIC SUBSTITUTED PYRIMIDINES | KRENITSKY PHARMACEUTICALS INC. (US) | 2000-10-19 | — | — | WO | disclosed |