Protionamide

Protionamide

SCHEMBL74572

CCCc1cc(C(N)=S)ccn1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 3/20 1.00
LMNA P02545 3/20 1.00
CYP3A4 P08684 1/20 1.00
TSHR P16473 1/20 1.00
CYP1A2 P05177 1/20 0.77
POLB P06746 1/20 0.77
SMN1; SMN2 Q16637 1/20 0.40
SREBF2 Q12772 10/20 0.40
MAPT P10636 3/20 0.37
ATM Q13315 3/20 0.37
L3MBTL1 Q9Y468 2/20 0.37
ALDH1A1 P00352 1/20 0.37
RECQL P46063 1/20 0.36
NOS2 P35228 1/20 0.36
KDM5A P29375 1/20 0.36
KDM5C P41229 1/20 0.36
KDM5D Q9BY66 1/20 0.36
KDM4C Q9H3R0 1/20 0.36
KDM5B Q9UGL1 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Protionamide SCHEMBL30271512 1.00 KDM4E (1.00) KDM4ELMNACYP3A4TSHRCYP1A2
SCHEMBL28093033 0.92 KDM4E (0.84) KDM4ELMNACYP3A4TSHRCYP1A2
SCHEMBL10491662 0.87 KDM4E (0.77) KDM4ELMNACYP3A4TSHRCYP1A2
Ethionamide SCHEMBL12264084 0.87 CYP1A2 (1.00) KDM4ELMNACYP3A4TSHRCYP1A2
Ethionamide SCHEMBL12264093 0.87 CYP1A2 (1.00) KDM4ELMNACYP3A4TSHRCYP1A2
Ethionamide SCHEMBL27007 0.87 CYP1A2 (1.00) KDM4ELMNACYP3A4TSHRCYP1A2
Ethionamide SCHEMBL12264091 0.87 CYP1A2 (1.00) KDM4ELMNACYP3A4TSHRCYP1A2
Ethionamide SCHEMBL12264086 0.87 CYP1A2 (1.00) KDM4ELMNACYP3A4TSHRCYP1A2
Ethionamide SCHEMBL12264090 0.87 CYP1A2 (1.00) KDM4ELMNACYP3A4TSHRCYP1A2
Ethionamide SCHEMBL12264085 0.87 CYP1A2 (1.00) KDM4ELMNACYP3A4TSHRCYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 3302 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260137766-A1 LIPOSOME FORMULATIONS FOR TREATMENT OF ACTIVE TUBERCULOSIS ARCHIVEL FARMA S L (ES) 2026-05-21 US claimed
EP-4736841-A1 A MUCOADHESIVE LAYER FOR BUCCAL ADMINISTRATION OF AN ACTIVE PHARMACEUTICAL INGREDIENT IQ medical GmbH (DE) 2026-05-06 EP claimed
EP-4727950-A1 HETEROCYCLIC COMPOUNDS AND THEIR USE IN THE TREATMENT OF MYCOBACTERIAL INFECTIONS GlaxoSmithKline Intellectual Property Development Ltd (GB) 2026-04-22 EP claimed
EP-4121058-B1 OXAZOLIDINONE COMPOUND AND ITS USE THEREOF AS AN ANTIBACTERIAL AGENT MERCK SHARP & DOHME LLC (US) 2026-02-18 EP claimed
US-20260035363-A1 COMPOUNDS AND METHODS OF USE THEREOF AS ANTIBACTERIAL AGENTS MERCK SHARP & DOHME LLC (US) 2026-02-05 US claimed
EP-4674846-A1 UREA MOTIF CONTAINING COMPOUNDS AS ANTIBACTERIAL DRUGS AGAINST MULTIRESISTANT MYCOBACTERIA Technische Universität München (DE) 2026-01-07 EP claimed
US-12459933-B2 Compounds and methods of use thereof as antibacterial agents MERCK SHARP & DOHME LLC (US) 2025-11-04 US claimed
US-12435077-B2 Oxazolidinone compound and methods of use thereof as an antibacterial agent MERCK SHARP & DOHME LLC (US) 2025-10-07 US claimed
EP-4601620-A1 LIPOSOME FORMULATIONS FOR TREATMENT OF ACTIVE TUBERCULOSIS Archivel Farma, S.l. (ES) 2025-08-20 EP claimed
US-12365656-B2 Oxazolidinone compounds and methods of use thereof as antibacterial agents MERCK SHARP & DOHME LLC (US) 2025-07-22 US claimed
WO-2001044272-A2 DAPTOMYCIN ANALOGS AS ANTIBACTERIAL AGENTS CUBIST PHARMACEUTICALS, INC. (US) 2001-06-21 WO claimed
WO-2001044274-A1 LIPOPEPTIDES AS ANTIBACTERIAL AGENTS CUBIST PHARMACEUTICALS, INC. (US) 2001-06-21 WO claimed
WO-2001044271-A2 DAPTOMYCIN ANALOGS AND THEIR USE AS ANTIBACTERIAL AGENTS CUBIST PHARMACEUTICALS, INC. (US) 2001-06-21 WO claimed
CN-1297352-A Use of organophosphorous compounds for the therapeutic and prophylactic treatment of infections HASSAN JOMAA (DE) 2001-05-30 CN claimed
CN-1264430-A Betaines as adjuvants to susceptibility testing and antimicrobial therapy INTEGRATED RES TECHNOLOGY PLC (US) 2000-08-23 CN claimed
US-6054133-A Anti-microbial targeting for intracellular pathogens THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2000-04-25 US claimed
WO-2000018419-A2 METHODS FOR ADMINISTRATION OF ANTIBIOTICS CUBIST PHARMACEUTICALS, INC. (US) 2000-04-06 WO claimed
EP-0980438-A1 BETAINES AS ADJUDVANTS TO SUSCEPTIBILITY TESTING AND ANTIMICROBIAL THERAPY Integrated Research Technology, LLC (US) 2000-02-23 EP claimed
WO-1998050576-A1 BETAINES AS ADJUVANTS TO SUSCEPTIBILITY TESTING AND ANTIMICROBIAL THERAPY INTEGRATED RESEARCH TECHNOLOGY, LLC (US) 1998-11-12 WO claimed
US-4005207-A ISONICOTINIC ACID HYDRAZIDE, 2-PROPYL THIO-ISONICOTINAMIDE, 4,4'-DIAMINODIPHENYL SULFONE SAARSTICKSTOFF-FATOL GMBH (DT) 1977-01-25 US claimed