⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8605609 | 0.88 | — | — | |
| SCHEMBL15417357 | 0.67 | — | — | |
| SCHEMBL19121793 | 0.67 | — | — | |
| SCHEMBL12409013 | 0.67 | — | — | |
| SCHEMBL8734417 | 0.67 | — | — | |
| SCHEMBL129698 | 0.67 | — | — | |
| SCHEMBL6243290 | 0.65 | — | — | |
| SCHEMBL7037577 | 0.63 | — | — | |
| SCHEMBL1593543 | 0.62 | — | — | |
| SCHEMBL13953080 | 0.62 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 82 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105980387-B | Serine/threonine kinase inhibitor | 阵列生物制药公司 | 2019-04-19 | — | — | CN | claimed |
| EP-3089980-B1 | SERINE/THREONINE KINASE INHIBITORS | ARRAY BIOPHARMA INC (US) | 2018-01-31 | — | — | EP | claimed |
| US-9670208-B2 | Serine/threonine kinase inhibitors | ARRAY BIOPHARMA INC. (US) | 2017-06-06 | — | — | US | claimed |
| EP-3089980-A1 | SERINE/THREONINE KINASE INHIBITORS | Array Biopharma, Inc. (US) | 2016-11-09 | — | — | EP | claimed |
| US-20160304519-A1 | SERINE/THREONINE KINASE INHIBITORS | ARRAY BIOPHARMA INC. (US) | 2016-10-20 | — | — | US | claimed |
| CN-105980387-A | Serine/threonine kinase inhibitors | 阵列生物制药公司 | 2016-09-28 | — | — | CN | claimed |
| WO-2015103137-A1 | SERINE/THREONINE KINASE INHIBITORS | ARRAY BIOPHARMA INC. (US) | 2015-07-09 | — | — | WO | claimed |
| CN-102026664-A | Composition of stabilized beta blocker and percutaneous absorption preparation containing the same | TEIKOKU SEIYAKU KK | 2011-04-20 | — | — | CN | claimed |
| CN-101679285-A | 3-cyclopropyl-4-(3-thiobenzoyl) pyrazoles and as the purposes of weedicide | BAYER CROPSCIENCE AG | 2010-03-24 | — | — | CN | claimed |
| CN-101316844-A | Inhibitors of diacylglycerol acyltransferase (DGAT) | HOFFMANN LA ROCHE (CH) | 2008-12-03 | — | — | CN | claimed |
| CN-1290847-C | Aza-aryl piperazines | HOFFMANN LA ROCHE (CH) | 2006-12-20 | — | — | CN | claimed |
| CN-1625558-A | Aza-arylpiperazines | HOFFMANN LA ROCHE (CH) | 2005-06-08 | — | — | CN | claimed |
| EP-1090005-A1 | PYRAZOLO 1,5-a]TRIAZINE CORTICOTROPIN RELEASING FACTOR ANTAGONISTS | Du Pont Pharmaceuticals Company (US) | 2001-04-11 | — | — | EP | claimed |
| WO-1999067247-A1 | PYRAZOLO[1,5-a]TRIAZINE CORTICOTROPIN RELEASING FACTOR ANTAGONISTS | DU PONT PHARMACEUTICALS COMPANY (US) | 1999-12-29 | — | — | WO | claimed |
| CN-106029667-B | Fused [1,4] diazepine compounds as Autotaxin (ATX) and lysophosphatidic acid (LPA) production inhibitors | 豪夫迈·罗氏有限公司 | 2019-08-23 | — | — | CN | disclosed |
| CN-105764905-B | Novel octahydro-cyclobutadieno [1, 2-c; 3, 4-c' ] dipyrrole-2-yl | 豪夫迈·罗氏有限公司 | 2019-06-07 | — | — | CN | disclosed |
| CN-105980387-B | Serine/threonine kinase inhibitor | 阵列生物制药公司 | 2019-04-19 | — | — | CN | disclosed |
| CN-1071433-A | The method for preparing digestive tract contractile motion stimulant | KITASATO INST (JP) | 1993-04-28 | — | — | CN | disclosed |
| CN-88101027-A | Growth promoting composition and preparation method thereof | — | 1988-08-31 | — | — | CN | disclosed |
| CN-86106828-A | DIGESTIVE TRACT CONTRACTILE MOTION STIMULANT | — | 1987-04-08 | — | — | CN | disclosed |