SCHEMBL7459083

SCHEMBL7459083

N[C@H]1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2ccccc2)C1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
TACR1 P25103 17/20 1.00
TACR3 P29371 1/20 0.58
USP2 O75604 2/20 0.46
RHOC P08134 1/20 0.46
RHOA P61586 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8297226 1.00 TACR1 (1.00) TACR1TACR3USP2RHOCRHOA
SCHEMBL8291732 0.89 TACR1 (0.81) TACR1TACR3RHOCRHOA
SCHEMBL3203637 0.89 TACR1 (0.81) TACR1TACR3RHOCRHOA
SCHEMBL8300981 0.89 TACR1 (0.81) TACR1TACR3RHOCRHOA
SCHEMBL4556039 0.89 TACR1 (0.81) TACR1TACR3RHOCRHOA
SCHEMBL9113036 0.88 TACR1 (0.78) TACR1TACR3USP2RHOCRHOA
SCHEMBL9112230 0.88 TACR1 (0.78) TACR1TACR3USP2RHOCRHOA
SCHEMBL13818185 0.87 TACR1 (0.77) TACR1TACR3USP2RHOCRHOA
SCHEMBL9111141 0.86 TACR1 (0.76) TACR1TACR3USP2RHOCRHOA
SCHEMBL8296860 0.86 TACR1 (0.75) TACR1TACR3RHOCRHOA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0739892-B1 Chromone derivatives NOVARTIS AG (CH) 2002-09-25 EP disclosed
US-5965562-A TREATING DISORDERS INDUCED BY SUBSTANCE P AND MIGRAINE HEADACHE NOVARTIS CORPORATION (US) 1999-10-12 US disclosed
US-5935951-A ANTAGONIST AGAINST SUBSTANCE P NOVARTIS FINANCE CORPORATION (US) 1999-08-10 US disclosed
EP-0707006-B1 Aroyl-piperidine derivatives NOVARTIS AG (CH) 1999-04-07 EP disclosed
US-5646144-A FOR TREATING DISORDERS IN WHICH SUBSTANCE P PLAYS A PART IN DEVELOPMENT CIBA-GEIGY CORPORATION (US) 1997-07-08 US disclosed
US-5604247-A NEUROKININE ANTAGONIST CIBA-GEIGY CORPORATION (US) 1997-02-18 US disclosed
EP-0739892-A2 Chromone derivatives CIBA-GEIGY AG (CH) 1996-10-30 EP disclosed
US-5541195-A SUBSTANCE P ANTAGONISTS CIBA-GEIGY CORPORATION (US) 1996-07-30 US disclosed
EP-0707006-A1 Aroyl-piperidine derivatives CIBA-GEIGY AG (CH) 1996-04-17 EP disclosed
EP-0532456-B1 1-Acylpiperidine derivatives and their use as substance P antagonists CIBA GEIGY AG (CH) 1995-03-29 EP disclosed
US-5310743-A Substance P antagonist CIBA-GEIGY CORP. (US) 1994-05-10 US disclosed
EP-0532456-A1 1-Acylpiperidine derivatives and their use as substance P antagonists CIBA-GEIGY AG (CH) 1993-03-17 EP disclosed