Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 10/20 | 0.68 |
| ▸ | FLT1 | P17948 | 10/20 | 0.68 |
| ▸ | KDR | P35968 | 10/20 | 0.68 |
| ▸ | EGFR | P00533 | 14/20 | 0.67 |
| ▸ | FLT4 | P35916 | 7/20 | 0.51 |
| ▸ | FGFR2 | P21802 | 3/20 | 0.51 |
| ▸ | FGFR4 | P22455 | 3/20 | 0.51 |
| ▸ | FGFR3 | P22607 | 3/20 | 0.51 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.48 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7460012 | 0.85 | RET (0.55) | FGFR1FLT1KDREGFRFLT4 | |
| SCHEMBL7459843 | 0.85 | KDR (0.64) | FGFR1FLT1KDREGFRFLT4 | |
| SCHEMBL7451653 | 0.84 | EGFR (0.59) | FGFR1FLT1KDREGFRFLT4 | |
| Hydrochloric Acid SCHEMBL7451614 | 0.84 | KDR (0.75) | FGFR1FLT1KDREGFRFLT4 | |
| SCHEMBL7451363 | 0.83 | KDR (0.77) | FGFR1FLT1KDREGFRFLT4 | |
| Hydrochloric Acid SCHEMBL7455267 | 0.82 | FLT1 (0.98) | FGFR1FLT1KDREGFRFLT4 | |
| SCHEMBL7451584 | 0.81 | FLT1 (1.00) | FGFR1FLT1KDREGFRFLT4 | |
| SCHEMBL7452247 | 0.81 | MAPK14 (0.58) | FGFR1FLT1KDREGFRFLT4 | |
| SCHEMBL17520362 | 0.81 | EGFR (1.00) | FGFR1FLT1KDREGFRFLT4 | |
| SCHEMBL11156 | 0.81 | EGFR (1.00) | FGFR1FLT1KDREGFRFLT4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6362336-B1 | ADMINISTERING A QUINAZOLINE DERIVATIVE TO A WARM-BLOODED ANIMAL FOR PRODUCING AN ANTIANGIOGENIC AND/OR VASCULAR PERMEABILITY REDUCING EFFECT | ZENECA LIMITED (GB) | 2002-03-26 | — | — | US | disclosed |
| US-20020032208-A1 | Chemical compounds | ZENECA LIMITED | 2002-03-14 | — | — | US | disclosed |
| EP-0873319-B1 | QUINAZOLINE DERIVATIVES | ASTRAZENECA AB (SE) | 2001-07-25 | — | — | EP | disclosed |
| US-6258951-B1 | ANTICANCER, ANTIARTHRITIC AGENTS | ZENECA LIMITED (GB) | 2001-07-10 | — | — | US | disclosed |
| US-6071921-A | Chemical compounds | ZENECA LIMITED (GB) | 2000-06-06 | — | — | US | disclosed |
| US-5962458-A | ANGIOGENESIS INHIBITORS, ANTICANCER AGENTS, ANTIDIABETIC AGENTS, SKIN DISORDERS, AUTOIMMUNE DISEASES, ANTIINFLAMMATORY AGENTS, VISION DEFECTS | ZENECA LIMITED (GB) | 1999-10-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020032208-A1 | Chemical compounds | FLT1, CNKSR1, KDR | FGFR1 95/4885FLT1 1/4885KDR 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.