Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | YTHDC1 | Q96MU7 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | JAK1 | P23458 | 1/20 | 0.33 |
| ▸ | TYK2 | P29597 | 1/20 | 0.33 |
| ▸ | JAK3 | P52333 | 1/20 | 0.33 |
| ▸ | PARP1 | P09874 | 1/20 | 0.32 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.32 |
| ▸ | BRD4 | O60885 | 1/20 | 0.32 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.32 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.32 |
| ▸ | FLT3 | P36888 | 1/20 | 0.31 |
| ▸ | CFTR | P13569 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.31 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.31 |
| ▸ | RET | P07949 | 1/20 | 0.31 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.31 |
| ▸ | PIM1 | P11309 | 1/20 | 0.31 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.31 |
| ▸ | GSK3B | P49841 | 1/20 | 0.31 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7451996 | 0.81 | KDM4E (0.42) | CREBBPKDM4EHPGDTSHRSMN1; SMN2 | |
| SCHEMBL7455406 | 0.78 | LCK (0.30) | — | |
| SCHEMBL3063009 | 0.77 | YTHDC1 (0.41) | YTHDC1PARP1PIN1BRD4NTRK1 | |
| SCHEMBL13651216 | 0.75 | KDM4E (0.48) | KDM4ETSHR | |
| SCHEMBL25086311 | 0.74 | YTHDC1 (0.42) | YTHDC1PIN1BRD4CREBBPFLT3 | |
| SCHEMBL15186359 | 0.74 | YTHDC1 (0.42) | YTHDC1PARP1PIN1BRD4CREBBP | |
| SCHEMBL13816862 | 0.73 | YTHDC1 (0.41) | YTHDC1PIN1BRD4CREBBPFLT3 | |
| SCHEMBL2385166 | 0.73 | CREBBP (0.42) | YTHDC1PIN1BRD4CREBBPCFTR | |
| SCHEMBL15112120 | 0.70 | YTHDC1 (0.39) | YTHDC1PIN1CREBBPCHEK1RET | |
| SCHEMBL13543760 | 0.69 | SLC6A2 (0.40) | YTHDC1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2580207-A1 | NITROGEN CONTAINING HETEROARYL COMPOUNDS | F. Hoffmann-La Roche AG (CH) | 2013-04-17 | — | — | EP | disclosed |
| WO-2011154327-A1 | NITROGEN CONTAINING HETEROARYL COMPOUNDS | F. HOFFMANN-LA ROCHE AG (CH) | 2011-12-15 | — | — | WO | disclosed |