Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 8/20 | 0.52 |
| ▸ | HTR1A | P08908 | 3/20 | 0.47 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.47 |
| ▸ | DRD2 | P14416 | 2/20 | 0.47 |
| ▸ | IDO1 | P14902 | 2/20 | 0.47 |
| ▸ | AGXT | P21549 | 2/20 | 0.47 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.44 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.44 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.44 |
| ▸ | BCHE | P06276 | 1/20 | 0.44 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.44 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.44 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.44 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.44 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.44 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.44 |
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.44 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7468357 | 0.84 | AGXT (0.43) | MAOBIDO1AGXTGABRG2GABRB3 | |
| SCHEMBL6810250 | 0.82 | MAOB (0.55) | MAOBHTR1AABCB1DRD2IDO1 | |
| SCHEMBL2202368 | 0.82 | MAOB (0.58) | MAOBHTR1AABCB1DRD2BCHE | |
| SCHEMBL7464303 | 0.81 | MAOB (0.44) | MAOBIDO1AGXTMRGPRX4NR4A2 | |
| SCHEMBL13722545 | 0.81 | MAOB (0.61) | MAOBHTR1AABCB1DRD2IDO1 | |
| SCHEMBL7464222 | 0.78 | FFAR1 (0.41) | MAOBIDO1AGXTHTTSMN1; SMN2 | |
| SCHEMBL27589325 | 0.77 | CYP3A4 (0.50) | MAOBABCB1 | |
| SCHEMBL13263642 | 0.76 | MAOB (0.79) | MAOBHTR1AABCB1DRD2IDO1 | |
| SCHEMBL7460676 | 0.76 | KDM4E (0.49) | HTR1AABCB1IDO1ADRA1DADRA1A | |
| SCHEMBL7461083 | 0.75 | MAOB (0.51) | MAOBHTR1AABCB1DRD2IDO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1244617-A1 | SUBSTITUTED AMINOALKYLAMIDE DERIVATIVES AS ANTAGONISTS OF FOLLICLE STIMULATING HORMONE | Ortho-McNeil Pharmaceutical, Inc. (US) | 2002-10-02 | — | — | EP | disclosed |
| WO-2001047875-A1 | SUBSTITUTED AMINOALKYLAMIDE DERIVATIVES AS ANTAGONISTS OF FOLLICLE STIMULATING HORMONE | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 2001-07-05 | — | — | WO | disclosed |