Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | MPO | P05164 | 7/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | CDK4 | P11802 | 1/20 | 0.45 |
| ▸ | CCND1 | P24385 | 1/20 | 0.45 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.45 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.45 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.44 |
| ▸ | HTR2A | P28223 | 1/20 | 0.44 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.44 |
| ▸ | CAPN2 | P17655 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL207031 | 0.88 | KDM4E (0.57) | KDM4EMPOTSHRSLC6A4ALDH1A1 | |
| SCHEMBL7461245 | 0.82 | F7 (0.65) | — | |
| SCHEMBL5912516 | 0.81 | KDM4E (0.64) | KDM4EMPOTSHRSLC6A4ALDH1A1 | |
| SCHEMBL7464145 | 0.80 | SLC6A4 (0.49) | SLC6A4HTR2A | |
| SCHEMBL785485 | 0.80 | KDM4E (0.62) | KDM4EMPOTSHRSLC6A4ALDH1A1 | |
| SCHEMBL24243764 | 0.79 | KDM4E (0.55) | KDM4EMPOTSHRSLC6A4ALDH1A1 | |
| SCHEMBL30622613 | 0.79 | KDM4E (0.55) | KDM4EMPOTSHRSLC6A4ALDH1A1 | |
| SCHEMBL784795 | 0.79 | KDM4E (0.81) | KDM4EMPOTSHRSLC6A4ALDH1A1 | |
| SCHEMBL7457775 | 0.78 | ALDH1A1 (0.62) | ALDH1A1SMN1; SMN2CDK4CCND1KMT2A | |
| SCHEMBL30877199 | 0.78 | ALDH1A1 (0.58) | KDM4EMPOTSHRSLC6A4ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1183252-A1 | NEW PHARMACEUTICALLY ACTIVE COMPOUNDS | AstraZeneca AB (SE) | 2002-03-06 | — | — | EP | disclosed |
| WO-2000071537-A1 | NEW PHARMACEUTICALLY ACTIVE COMPOUNDS | ASTRAZENECA AB (SE) | 2000-11-30 | — | — | WO | disclosed |