Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 3/20 | 0.60 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.60 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | POLB | P06746 | 1/20 | 0.57 |
| ▸ | PDE4A | P27815 | 4/20 | 0.52 |
| ▸ | ADORA2A | P29274 | 4/20 | 0.52 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.52 |
| ▸ | PDE4C | Q08493 | 4/20 | 0.52 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | BRD4 | O60885 | 4/20 | 0.49 |
| ▸ | BRD2 | P25440 | 2/20 | 0.49 |
| ▸ | BRD3 | Q15059 | 2/20 | 0.49 |
| ▸ | BRDT | Q58F21 | 2/20 | 0.49 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7454900 | 0.87 | SMN1; SMN2 (0.61) | MAPK1CYP3A4PMP22SMN1; SMN2KDM4E | |
| SCHEMBL7464093 | 0.86 | MAPK1 (0.57) | MAPK1CYP3A4PMP22SMN1; SMN2KDM4E | |
| SCHEMBL381684 | 0.83 | PDE4A (0.71) | MAPK1CYP3A4PMP22SMN1; SMN2KDM4E | |
| SCHEMBL1495090 | 0.82 | PDE4A (0.76) | MAPK1CYP3A4PMP22SMN1; SMN2KDM4E | |
| SCHEMBL10955005 | 0.82 | MAPK1 (0.64) | MAPK1CYP3A4PMP22SMN1; SMN2KDM4E | |
| SCHEMBL16675435 | 0.82 | MAPK1 (0.64) | MAPK1CYP3A4PMP22SMN1; SMN2KDM4E | |
| SCHEMBL17609493 | 0.81 | SMN1; SMN2 (0.55) | MAPK1CYP3A4PMP22SMN1; SMN2KDM4E | |
| SCHEMBL17682216 | 0.81 | SMN1; SMN2 (0.64) | MAPK1CYP3A4PMP22SMN1; SMN2KDM4E | |
| SCHEMBL9391065 | 0.79 | MAPK1 (0.60) | MAPK1CYP3A4PMP22SMN1; SMN2KDM4E | |
| SCHEMBL4566277 | 0.79 | MEN1 (0.77) | MAPK1CYP3A4PMP22SMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0771813-B1 | Alkylxanthine phosphonates and alkylxanthine phosphine oxydes and their use as medicines | HOECHST AG (DE) | 2002-01-16 | — | — | EP | disclosed |
| US-5783647-A | POLYMERIZATION CATALYST FOR VINYL CHLORIDE POLYMERS, SHORTER REACTION TIMES, IMPROVED COLOR AND LESS ODOR WHEN MOLDED | SHIN-ETSU CHEMICAL CO., LTD. (JP) | 1998-07-21 | — | — | US | disclosed |
| US-5728686-A | TREATMENT OF MUSCULAR DYSTROPHY | HOECHST AKTIENGESELLSCHAFT (DE) | 1998-03-17 | — | — | US | disclosed |
| US-5710272-A | INCREASING CEREBRAL BLOOD FLOW | HOECHST AKTIENGESELLSCHAFT (DE) | 1998-01-20 | — | — | US | disclosed |
| EP-0771813-A1 | Alkylxanthine phosphonates and alkylxanthine phosphine oxydes and their use as medicines | HOECHST AKTIENGESELLSCHAFT (DE) | 1997-05-07 | — | — | EP | disclosed |
| EP-0435152-B1 | Process for the enantioselective preparation of (omega-1)-hydroxyalkylxanthines | HOECHST AG (DE) | 1996-11-13 | — | — | EP | disclosed |
| US-5472873-A | Rhodotorula rubra useful in a process for the preparation of (ω-1)-hydroxyalkylxanthines | HOECHST AKTIENGESELLSCHAFT (DE) | 1995-12-05 | — | — | US | disclosed |
| US-5310666-A | Vascular disorders | HOECHST AKTIENGESELLSCHAFT (DE) | 1994-05-10 | — | — | US | disclosed |
| EP-0435152-A2 | Process for the enantioselective preparation of (omega-1)-hydroxyalkylxanthines | HOECHST AKTIENGESELLSCHAFT (DE) | 1991-07-03 | — | — | EP | disclosed |