Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.61 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.60 |
| ▸ | LMNA | P02545 | 1/20 | 0.60 |
| ▸ | POLB | P06746 | 1/20 | 0.60 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.59 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.59 |
| ▸ | PDE4A | P27815 | 4/20 | 0.55 |
| ▸ | ADORA2A | P29274 | 4/20 | 0.55 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.55 |
| ▸ | PDE4C | Q08493 | 4/20 | 0.55 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.55 |
| ▸ | MEN1 | O00255 | 3/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | BRD4 | O60885 | 1/20 | 0.48 |
| ▸ | BRD2 | P25440 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7461429 | 0.87 | MAPK1 (0.60) | SMN1; SMN2MAPK1KDM4ELMNAPOLB | |
| SCHEMBL9565477 | 0.85 | PDE4A (0.65) | SMN1; SMN2MAPK1KDM4ELMNAPOLB | |
| SCHEMBL1495090 | 0.84 | PDE4A (0.76) | SMN1; SMN2MAPK1KDM4ELMNAPOLB | |
| SCHEMBL17682216 | 0.82 | SMN1; SMN2 (0.64) | SMN1; SMN2MAPK1KDM4ELMNAPOLB | |
| SCHEMBL381684 | 0.82 | PDE4A (0.71) | SMN1; SMN2MAPK1KDM4ELMNAPOLB | |
| SCHEMBL4566277 | 0.81 | MEN1 (0.77) | SMN1; SMN2MAPK1KDM4ELMNAPOLB | |
| SCHEMBL16675435 | 0.81 | MAPK1 (0.64) | SMN1; SMN2MAPK1KDM4ELMNAPOLB | |
| SCHEMBL10955005 | 0.81 | MAPK1 (0.64) | SMN1; SMN2MAPK1KDM4ELMNAPOLB | |
| SCHEMBL25286006 | 0.80 | ALDH1A1 (0.71) | SMN1; SMN2MAPK1KDM4ELMNAPOLB | |
| SCHEMBL7455166 | 0.80 | SMN1; SMN2 (0.61) | SMN1; SMN2MAPK1KDM4ELMNAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0771813-B1 | Alkylxanthine phosphonates and alkylxanthine phosphine oxydes and their use as medicines | HOECHST AG (DE) | 2002-01-16 | — | — | EP | disclosed |
| US-5728686-A | TREATMENT OF MUSCULAR DYSTROPHY | HOECHST AKTIENGESELLSCHAFT (DE) | 1998-03-17 | — | — | US | disclosed |
| CN-1158855-A | Alkylxanthine phosphonates and alkylxanthine phosphine oxides and their use as pharmacueticals | HOECHST AG (DE) | 1997-09-10 | — | — | CN | disclosed |
| EP-0771813-A1 | Alkylxanthine phosphonates and alkylxanthine phosphine oxydes and their use as medicines | HOECHST AKTIENGESELLSCHAFT (DE) | 1997-05-07 | — | — | EP | disclosed |