⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2894160 | 0.73 | — | — | |
| SCHEMBL971263 | 0.71 | — | — | |
| SCHEMBL991144 | 0.70 | — | — | |
| SCHEMBL17074430 | 0.69 | — | — | |
| SCHEMBL2444699 | 0.69 | — | — | |
| SCHEMBL451341 | 0.67 | — | — | |
| SCHEMBL971203 | 0.66 | — | — | |
| SCHEMBL4990370 | 0.65 | MALT1 (0.33) | — | |
| SCHEMBL11890123 | 0.62 | — | — | |
| SCHEMBL1515054 | 0.62 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 65 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3353174-A1 | N-[2-(3-AMINO-2,5-DIMETHYL-1,1-DIOXIDO-5,6-DIHYDRO-2H-1,2,4-THIADIAZIN-5-YL)-1,3-THIAZOL-4-YL]AMIDES USEFUL AS BACE INHIBITORS | Pfizer Inc (US) | 2018-08-01 | — | — | EP | claimed |
| EP-2864324-B1 | DIFLUORO-HEXAHYDRO-CYCLOPENTAOXAZINYLS AND DIFLUORO-HEXAHYDRO-BENZOOXAZINYLS AS BACE1 INHIBITORS | HOFFMANN LA ROCHE (CH) | 2018-03-28 | — | — | EP | claimed |
| WO-2017051294-A1 | N-[2-(3-AMINO-2,5-DIMETHYL-1,1-DIOXIDO-5,6-DIHYDRO-2H-1,2,4-THIADIAZIN-5-YL)-1,3-THIAZOL-4-YL] AMIDES USEFUL AS BACE INHIBITORS | PFIZER INC. (US) | 2017-03-30 | — | — | WO | claimed |
| US-9181232-B2 | Difluoro-hexahydro-cyclopentaoxazinyls and difluoro-hexahydro-benzooxazinyls as BACE1 inhibitors | HOFFMANN-LA ROCHE INC. (US) | 2015-11-10 | — | — | US | claimed |
| US-9067926-B2 | Fluoromethyl-5,6-dihydro-4H-[1,3]OXAZINES | HOFFMANN-LA ROCHE INC. (US) | 2015-06-30 | — | — | US | claimed |
| US-20150133440-A1 | DIFLUORO-HEXAHYDRO-CYCLOPENTAOXAZINYLS AND DIFLUORO-HEXAHYDRO-BENZOOXAZINYLS AS BACE1 INHIBITORS | HOFFMANN-LA ROCHE INC. (US) | 2015-05-14 | — | — | US | claimed |
| EP-2864324-A1 | DIFLUORO-HEXAHYDRO-CYCLOPENTAOXAZINYLS AND DIFLUORO-HEXAHYDRO-BENZOOXAZINYLS AS BACE1 INHIBITORS | F. Hoffmann-La Roche AG (CH) | 2015-04-29 | — | — | EP | claimed |
| US-20150031690-A1 | FLUOROMETHYL-5,6-DIHYDRO-4H-[1,3]OXAZINES | F. HOFFMANN-LA ROCHE AG (CH) | 2015-01-29 | — | — | US | claimed |
| EP-2807155-A1 | FLUOROMETHYL-5,6-DIHYDRO-4H-[1,3]OXAZINES | F.HOFFMANN-LA ROCHE AG (CH) | 2014-12-03 | — | — | EP | claimed |
| WO-2014001228-A1 | DIFLUORO-HEXAHYDRO-CYCLOPENTAOXAZINYLS AND DIFLUORO-HEXAHYDRO-BENZOOXAZINYLS AS BACE1 INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2014-01-03 | — | — | WO | claimed |
| WO-2013110622-A1 | FLUOROMETHYL-5,6-DIHYDRO-4H-[1,3]OXAZINES | F. HOFFMANN-LA ROCHE AG (CH) | 2013-08-01 | — | — | WO | claimed |
| US-20130116230-A1 | 3-AMINOPYRROLIDINE DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTORS | INCYTE CORPORATION (US) | 2013-05-09 | — | — | US | claimed |
| US-8362003-B2 | 3-aminopyrrolidine derivatives as modulators of chemokine receptors | INCYTE CORPORATION (US) | 2013-01-29 | — | — | US | claimed |
| EP-2431357-A2 | 3-Aminopyrrolidine Derivatives as Modulators of Chemokine Receptors | Incyte Corporation (US) | 2012-03-21 | — | — | EP | claimed |
| US-20110251168-A1 | 3-AMINOPYRROLIDINE DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTORS | INCYTE CORPORATION | 2011-10-13 | — | — | US | claimed |
| EP-1565436-A4 | 3-AMINOPYRROLIDINE DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTORS | INCYTE CORP (US) | 2007-07-18 | — | — | EP | claimed |
| US-20060252751-A1 | 3-Aminopyrrolidine derivaties as modulators of chemokine receptors | INCYTE HOLDINGS CORPORATION | 2006-11-09 | — | — | US | claimed |
| JP-2006516145-A | — | — | 2006-06-22 | — | — | JP | claimed |
| EP-1565436-A2 | 3-AMINOPYRROLIDINE DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTORS | INCYTE CORPORATION (US) | 2005-08-24 | — | — | EP | claimed |
| WO-2004050024-A2 | 3-AMINOPYRROLIDINE DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTORS | INCYTE CORPORATION (US) | 2004-06-17 | — | — | WO | claimed |