⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL992408 | 0.77 | — | — | |
| SCHEMBL11779433 | 0.74 | GABRP (0.35) | — | |
| SCHEMBL17458709 | 0.74 | CNR2 (0.30) | — | |
| SCHEMBL16540995 | 0.72 | POLB (0.40) | — | |
| SCHEMBL990506 | 0.71 | — | — | |
| SCHEMBL15142636 | 0.71 | — | — | |
| SCHEMBL746155 | 0.70 | — | — | |
| SCHEMBL11902638 | 0.70 | ADAM17 (0.31) | — | |
| SCHEMBL451341 | 0.65 | — | — | |
| SCHEMBL1976211 | 0.65 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 36 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9067926-B2 | Fluoromethyl-5,6-dihydro-4H-[1,3]OXAZINES | HOFFMANN-LA ROCHE INC. (US) | 2015-06-30 | — | — | US | claimed |
| US-20150031690-A1 | FLUOROMETHYL-5,6-DIHYDRO-4H-[1,3]OXAZINES | F. HOFFMANN-LA ROCHE AG (CH) | 2015-01-29 | — | — | US | claimed |
| EP-2807155-A1 | FLUOROMETHYL-5,6-DIHYDRO-4H-[1,3]OXAZINES | F.HOFFMANN-LA ROCHE AG (CH) | 2014-12-03 | — | — | EP | claimed |
| WO-2013110622-A1 | FLUOROMETHYL-5,6-DIHYDRO-4H-[1,3]OXAZINES | F. HOFFMANN-LA ROCHE AG (CH) | 2013-08-01 | — | — | WO | claimed |
| EP-2807155-B1 | FLUOROMETHYL-5,6-DIHYDRO-4H-[1,3]OXAZINES | HOFFMANN LA ROCHE (CH) | 2017-04-12 | — | — | EP | disclosed |
| US-20150322054-A1 | 1,3-Oxazines As Bace1 And/Or Bace2 Inhibitors | HOFFMANN-LA ROCHE INC. | 2015-11-12 | — | — | US | disclosed |
| US-9139594-B2 | Fused aminodihydropyrimidone derivatives | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2015-09-22 | — | — | US | disclosed |
| US-9115098-B2 | 1,3-oxazines as BACE1 and/or BACE2 inhibitors | HOFFMAN-LA ROCHE INC. (US) | 2015-08-25 | — | — | US | disclosed |
| US-9079914-B2 | Fused aminodihydro-oxazine derivatives | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2015-07-14 | — | — | US | disclosed |
| US-9067926-B2 | Fluoromethyl-5,6-dihydro-4H-[1,3]OXAZINES | HOFFMANN-LA ROCHE INC. (US) | 2015-06-30 | — | — | US | disclosed |
| US-20150031690-A1 | FLUOROMETHYL-5,6-DIHYDRO-4H-[1,3]OXAZINES | F. HOFFMANN-LA ROCHE AG (CH) | 2015-01-29 | — | — | US | disclosed |
| EP-2807155-A1 | FLUOROMETHYL-5,6-DIHYDRO-4H-[1,3]OXAZINES | F.HOFFMANN-LA ROCHE AG (CH) | 2014-12-03 | — | — | EP | disclosed |
| US-20120202828-A1 | FUSED AMINODIHYDROPYRIMIDONE DERIVATIVES | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2012-08-09 | — | — | US | disclosed |
| US-20120202804-A1 | FUSED AMINODIHYDRO-OXAZINE DERIVATIVES | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2012-08-09 | — | — | US | disclosed |
| EP-2456771-A1 | FUSED AMINODIHYDROPYRIMIDONE DERIVATIVES | Eisai R&D Management Co., Ltd. (JP) | 2012-05-30 | — | — | EP | disclosed |
| EP-2456774-A1 | FUSED AMINODIHYDRO-OXAZINE DERIVATIVES | Eisai R&D Management Co., Ltd. (JP) | 2012-05-30 | — | — | EP | disclosed |
| US-20110312937-A1 | 2,5,6,7-TETRAHYDRO-[1,4]OXAZEPIN-3-YLAMINE OR 2,3,6,7-TETRAHYDRO-[1,4]OXAZEPIN-5-YLAMINE COMPOUNDS | SIENA BIOTECH S.P.A. (IT) | 2011-12-22 | — | — | US | disclosed |
| WO-2011138293-A1 | 2,5,6,7-TETRAHYDRO-[1,4]OXAZEPIN-3-YLAMINE OR 2,3,6,7-TETRAHYDRO-[1,4]OXAZEPIN-5-YLAMINE COMPOUNDS | F. HOFFMANN-LA ROCHE AG (CH) | 2011-11-10 | — | — | WO | disclosed |
| WO-2011009897-A1 | FUSED AMINODIHYDROPYRIMIDONE DERIVATIVES | EISAI R&D MANAGEMENT CO., LTD (JP) | 2011-01-27 | — | — | WO | disclosed |
| WO-2011009898-A1 | FUSED AMINODIHYDRO-OXAZINE DERIVATIVES | EISAI R&D MANAGEMENT CO., LTD (JP) | 2011-01-27 | — | — | WO | disclosed |