Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 3/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.31 |
| ▸ | NAT1 | P18440 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7455759 | 0.99 | MAPT (0.36) | MAPTSMN1; SMN2POLBADRA2BMEN1 | |
| SCHEMBL7459664 | 0.86 | MAPT (0.43) | MAPTSMN1; SMN2ADRA2BMEN1KMT2A | |
| SCHEMBL7460493 | 0.85 | ADRA2B (0.37) | MAPTADRA2BMEN1KMT2AALDH1A1 | |
| Hydrochloric Acid SCHEMBL7456853 | 0.85 | MAPT (0.42) | MAPTSMN1; SMN2ADRA2BMEN1KMT2A | |
| Hydrochloric Acid SCHEMBL7455787 | 0.84 | ADRA2B (0.36) | MAPTADRA2BMEN1KMT2AALDH1A1 | |
| SCHEMBL7451451 | 0.83 | NPC1 (0.40) | MAPTSMN1; SMN2POLBADRA2BMEN1 | |
| SCHEMBL7451416 | 0.82 | CA1 (0.37) | MAPTADRA2BMEN1KMT2AALDH1A1 | |
| SCHEMBL7452886 | 0.82 | ADRA2B (0.33) | MAPTSMN1; SMN2POLBADRA2BMEN1 | |
| SCHEMBL7456555 | 0.82 | APP (0.40) | MAPTADRA2BMEN1KMT2AALDH1A1 | |
| SCHEMBL7455072 | 0.82 | RPS6KA2 (0.46) | MAPTSMN1; SMN2MEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1210598-A4 | 4-UNSUBSTITUTED DIHYDROISOQUINOLINONE DERIVATIVES AND COMBINATORIAL LIBRARIES THEREOF | LION BIOSCIENCE AG (DE) | 2002-10-30 | — | — | EP | claimed |
| US-6452009-B1 | A LARGE NUMBER OF RELATED ANALOGS ARE THEN SYNTHESIZED IN ORDER TO DEVELOP A STRUCTURE-ACTIVITY RELATIONSHIP | LION BIOSCIENCE AG (DE) | 2002-09-17 | — | — | US | claimed |
| EP-1210598-A1 | 4-UNSUBSTITUTED DIHYDROISOQUINOLINONE DERIVATIVES AND COMBINATORIAL LIBRARIES THEREOF | LION bioscience AG (DE) | 2002-06-05 | — | — | EP | claimed |
| EP-0963982-B1 | New diaminobenzene derivatives and these componends containing colouring agents | WELLA AG (DE) | 2002-03-13 | — | — | EP | claimed |
| WO-2001014879-A1 | 4-UNSUBSTITUTED DIHYDROISOQUINOLINONE DERIVATIVES AND COMBINATORIAL LIBRARIES THEREOF | LION BIOSCIENCE AG (DE) | 2001-03-01 | — | — | WO | claimed |
| US-6132475-A | FOR OXIDATION DYEING OF KERATIN FIBERS; INCLUDES COUPLER AND DEVELOPER, IN WHICH THE DEVELOPER IS A SUBSTITUTED 2-(FURYL, THIENYL, PYRROLYL, OR SELENOPHENE) P-DIAMINOBENZENE DERIVATIVE OF GIVEN FORMULA; COLORFASTNESS, WASHFASTNESS | WELLA AKTIENGESELLSCHAFT (DE) | 2000-10-17 | — | — | US | claimed |
| EP-0963982-A2 | New diaminobenzene derivatives and these componends containing colouring agents | Wella Aktiengesellschaft (DE) | 1999-12-15 | — | — | EP | claimed |
| WO-2014152824-A1 | POLYHETEROSILOXANE COMPOSITION AND SILICONE COMPOSITION INCLUDING A POLYHETEROSILOXANE | DOW CORNING CORPORATION (US) | 2014-09-25 | — | — | WO | disclosed |
| WO-2013192404-A1 | POLYHETEROSILOXANE COMPOSITION | DOW CORNING CORPORATION (US) | 2013-12-27 | — | — | WO | disclosed |
| EP-1210598-A4 | 4-UNSUBSTITUTED DIHYDROISOQUINOLINONE DERIVATIVES AND COMBINATORIAL LIBRARIES THEREOF | LION BIOSCIENCE AG (DE) | 2002-10-30 | — | — | EP | disclosed |
| US-6452009-B1 | A LARGE NUMBER OF RELATED ANALOGS ARE THEN SYNTHESIZED IN ORDER TO DEVELOP A STRUCTURE-ACTIVITY RELATIONSHIP | LION BIOSCIENCE AG (DE) | 2002-09-17 | — | — | US | disclosed |
| EP-1210598-A1 | 4-UNSUBSTITUTED DIHYDROISOQUINOLINONE DERIVATIVES AND COMBINATORIAL LIBRARIES THEREOF | LION bioscience AG (DE) | 2002-06-05 | — | — | EP | disclosed |
| EP-0963982-B1 | New diaminobenzene derivatives and these componends containing colouring agents | WELLA AG (DE) | 2002-03-13 | — | — | EP | disclosed |
| WO-2001014879-A1 | 4-UNSUBSTITUTED DIHYDROISOQUINOLINONE DERIVATIVES AND COMBINATORIAL LIBRARIES THEREOF | LION BIOSCIENCE AG (DE) | 2001-03-01 | — | — | WO | disclosed |
| US-6132475-A | FOR OXIDATION DYEING OF KERATIN FIBERS; INCLUDES COUPLER AND DEVELOPER, IN WHICH THE DEVELOPER IS A SUBSTITUTED 2-(FURYL, THIENYL, PYRROLYL, OR SELENOPHENE) P-DIAMINOBENZENE DERIVATIVE OF GIVEN FORMULA; COLORFASTNESS, WASHFASTNESS | WELLA AKTIENGESELLSCHAFT (DE) | 2000-10-17 | — | — | US | disclosed |
| EP-0963982-A2 | New diaminobenzene derivatives and these componends containing colouring agents | Wella Aktiengesellschaft (DE) | 1999-12-15 | — | — | EP | disclosed |