Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR2 | P21452 | 8/20 | 0.41 |
| ▸ | TACR1 | P25103 | 7/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | HRH1 | P35367 | 2/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | TACR3 | P29371 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7462757 | 0.93 | TACR2 (0.43) | TACR2TACR1ALDH1A1HRH1TACR3 | |
| SCHEMBL6997001 | 0.90 | TACR2 (0.51) | TACR2TACR1HRH1TACR3 | |
| SCHEMBL6996994 | 0.90 | TACR2 (0.51) | TACR2TACR1HRH1TACR3 | |
| SCHEMBL7468621 | 0.90 | TACR2 (0.51) | TACR2TACR1HRH1TACR3 | |
| SCHEMBL7463741 | 0.90 | TACR2 (0.39) | TACR2TACR1ALDH1A1HRH1TACR3 | |
| SCHEMBL8632785 | 0.90 | TACR2 (0.40) | TACR2TACR1ALDH1A1HRH1TACR3 | |
| SCHEMBL6992108 | 0.89 | TACR2 (0.46) | TACR2TACR1HRH1TACR3 | |
| SCHEMBL8444592 | 0.83 | TACR2 (0.54) | TACR2TACR1HRH1TACR3 | |
| SCHEMBL7461790 | 0.83 | TACR2 (0.40) | TACR2TACR1ALDH1A1HRH1TACR3 | |
| SCHEMBL7465298 | 0.83 | TACR2 (0.48) | TACR2TACR1HRH1TACR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0946548-B1 | NOVEL HETEROCYCLIC SUBSTITUTED PYRROLIDINE AMIDE DERIVATIVES | AVENTIS PHARMA INC (US) | 2002-03-06 | — | — | EP | disclosed |
| EP-0946548-A1 | NOVEL HETEROCYCLIC SUBSTITUTED PYRROLIDINE AMIDE DERIVATIVES | HOECHST MARION ROUSSEL, INC. (US) | 1999-10-06 | — | — | EP | disclosed |
| US-5861417-A | TACHYKININ RECEPTOR ANTAGONISTS USEFUL IN TREATING ASTHMA, COUGH, BRONCHITIS, PAIN | HOECHST MARION ROUSSEL, INC. (US) | 1999-01-19 | — | — | US | disclosed |
| WO-1998027086-A1 | NOVEL HETEROCYCLIC SUBSTITUTED PYRROLIDINE AMIDE DERIVATIVES | HOECHST MARION ROUSSEL, INC. (US) | 1998-06-25 | — | — | WO | disclosed |