Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 12/20 | 0.42 |
| ▸ | EGFR | P00533 | 6/20 | 0.41 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.41 |
| ▸ | KDM5A | P29375 | 1/20 | 0.36 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4052545 | 0.88 | KDR (0.56) | KDREGFRERBB2 | |
| SCHEMBL5606311 | 0.72 | KDR (0.42) | KDREGFRERBB2 | |
| SCHEMBL14033317 | 0.68 | PIK3CA (0.40) | KDRKDM5AKDM5B | |
| SCHEMBL23377915 | 0.67 | PGR (0.38) | — | |
| SCHEMBL5596370 | 0.67 | KDR (0.80) | KDRERBB2 | |
| SCHEMBL16800773 | 0.67 | EGFR (0.66) | KDREGFRERBB2 | |
| SCHEMBL27888134 | 0.67 | EGFR (0.63) | KDREGFRERBB2 | |
| SCHEMBL5606088 | 0.65 | KDR (0.47) | KDREGFR | |
| SCHEMBL5606960 | 0.64 | KDR (0.80) | KDRERBB2 | |
| SCHEMBL17889767 | 0.64 | KDM5A (0.45) | EGFRKDM5AKDM5B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1351498-B | Pyrrolotriazines inhibitors of kinases | BRISTOL MYERS SQUIBB CO | 2012-08-15 | — | — | CN | disclosed |
| EP-1183033-A4 | PYRROLOTRIAZINE INHIBITORS OF KINASES | BRISTOL MYERS SQUIBB CO (US) | 2002-07-17 | — | — | EP | disclosed |
| EP-1183033-A1 | PYRROLOTRIAZINE INHIBITORS OF KINASES | BRISTOL-MYERS SQUIBB COMPANY (US) | 2002-03-06 | — | — | EP | disclosed |
| WO-2000071129-A1 | PYRROLOTRIAZINE INHIBITORS OF KINASES | BRISTOL-MYERS SQUIBB COMPANY (US) | 2000-11-30 | — | — | WO | disclosed |