Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SREBF1 | P36956 | 1/20 | 0.43 |
| ▸ | SREBF2 | Q12772 | 1/20 | 0.43 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | UHRF1 | Q96T88 | 1/20 | 0.42 |
| ▸ | CCR1 | P32246 | 1/20 | 0.42 |
| ▸ | CCR5 | P51681 | 1/20 | 0.42 |
| ▸ | CCR8 | P51685 | 1/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.40 |
| ▸ | NOS2 | P35228 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | NOS3 | P29474 | 1/20 | 0.39 |
| ▸ | NOS1 | P29475 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | KDM1A | O60341 | 1/20 | 0.39 |
| ▸ | MAOA | P21397 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12596 | 0.88 | — | — | |
| SCHEMBL31421768 | 0.88 | — | — | |
| SCHEMBL10272612 | 0.87 | SREBF1 (0.49) | SREBF1SREBF2CYP1A2POLBMAPK14 | |
| SCHEMBL27440094 | 0.86 | UHRF1 (0.50) | SREBF1SREBF2CYP1A2POLBUHRF1 | |
| Bromide SCHEMBL28271991 | 0.86 | UHRF1 (0.50) | SREBF1SREBF2CYP1A2POLBUHRF1 | |
| SCHEMBL31555358 | 0.78 | CYP1A2 (0.52) | SREBF1SREBF2CYP1A2POLBNOS2 | |
| SCHEMBL8257156 | 0.77 | SREBF2 (0.48) | SREBF1SREBF2CYP1A2POLB | |
| SCHEMBL11176714 | 0.75 | MAP4K4 (0.49) | SREBF1SREBF2CYP1A2POLBMEN1 | |
| SCHEMBL11372896 | 0.75 | SREBF2 (0.54) | SREBF2CYP1A2POLB | |
| SCHEMBL17826980 | 0.75 | CNR2 (0.47) | SREBF1SREBF2CYP1A2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0770065-A1 | TRI-SUBSTITUTED PHENYL DERIVATES USEFUL AS PDE IV INHIBITORS | CELLTECH THERAPEUTICS LIMITED (GB) | 1997-05-02 | — | — | EP | disclosed |
| WO-1995035281-A1 | TRI-SUBSTITUTED PHENYL DERIVATES USEFUL AS PDE IV INHIBITORS | CELLTECH THERAPEUTICS LIMITED (GB) | 1995-12-28 | — | — | WO | disclosed |