Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIA1 | P42261 | 4/20 | 0.49 |
| ▸ | GRIA2 | P42262 | 4/20 | 0.49 |
| ▸ | GRIA3 | P42263 | 4/20 | 0.49 |
| ▸ | GRIA4 | P48058 | 4/20 | 0.49 |
| ▸ | GRIN2D | O15399 | 11/20 | 0.47 |
| ▸ | GRIN3B | O60391 | 11/20 | 0.47 |
| ▸ | GRIN1 | Q05586 | 11/20 | 0.47 |
| ▸ | GRIN2A | Q12879 | 11/20 | 0.47 |
| ▸ | GRIN2B | Q13224 | 11/20 | 0.47 |
| ▸ | GRIN2C | Q14957 | 11/20 | 0.47 |
| ▸ | GRIN3A | Q8TCU5 | 11/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.42 |
| ▸ | BLM | P54132 | 1/20 | 0.42 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7465894 | 0.93 | GRIA1 (0.51) | GRIA1GRIA2GRIA3GRIA4GRIN2D | |
| SCHEMBL7460818 | 0.88 | GRIA1 (0.53) | GRIA1GRIA2GRIA3GRIA4GRIN2D | |
| SCHEMBL7464140 | 0.83 | GRIA1 (0.55) | GRIA1GRIA2GRIA3GRIA4GRIN2D | |
| SCHEMBL7532574 | 0.81 | GRIA1 (0.49) | GRIA1GRIA2GRIA3GRIA4GRIN2D | |
| SCHEMBL7958054 | 0.79 | GRIA1 (0.56) | GRIA1GRIA2GRIA3GRIA4GRIN2D | |
| SCHEMBL7957837 | 0.79 | GRIA1 (0.51) | GRIA1GRIA2GRIA3GRIA4GRIN2D | |
| SCHEMBL8056142 | 0.78 | GRIA1 (0.50) | GRIA1GRIA2GRIA3GRIA4GRIN2D | |
| SCHEMBL7948153 | 0.76 | GRIA1 (0.61) | GRIA1GRIA2GRIA3GRIA4GRIN2D | |
| SCHEMBL499361 | 0.76 | GRIN2D (0.55) | GRIA1GRIA2GRIA3GRIA4GRIN2D | |
| Hydrochloric Acid SCHEMBL4931576 | 0.75 | GRIN2D (0.54) | GRIA1GRIA2GRIA3GRIA4GRIN2D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0837854-B1 | ALKYL AMINE DERIVATIVES OF SUBSTITUTED QUINOXALINE 2,3-DIONES AS GLUTAMATE RECEPTOR ANTAGONISTS | WARNER LAMBERT CO (US) | 2002-12-11 | — | — | EP | claimed |
| EP-0837854-A1 | ALKYL AMINE DERIVATIVES OF SUBSTITUTED QUINOXALINE 2,3-DIONES AS GLUTAMATE RECEPTOR ANTAGONISTS | WARNER-LAMBERT COMPANY (US) | 1998-04-29 | — | — | EP | claimed |
| US-5654303-A | FOR TREATING NERVOUS SYSTEM OR CARDIOVASCULAR SYSTEM DISORDERS | WARNER-LAMBERT COMPANY (US) | 1997-08-05 | — | — | US | claimed |
| WO-1996040651-A1 | ALKYL AMINE DERIVATIVES OF SUBSTITUTED QUINOXALINE 2,3-DIONES AS GLUTAMATE RECEPTOR ANTAGONISTS | WARNER-LAMBERT COMPANY (US) | 1996-12-19 | — | — | WO | claimed |
| EP-0837854-B1 | ALKYL AMINE DERIVATIVES OF SUBSTITUTED QUINOXALINE 2,3-DIONES AS GLUTAMATE RECEPTOR ANTAGONISTS | WARNER LAMBERT CO (US) | 2002-12-11 | — | — | EP | disclosed |
| EP-0837854-A1 | ALKYL AMINE DERIVATIVES OF SUBSTITUTED QUINOXALINE 2,3-DIONES AS GLUTAMATE RECEPTOR ANTAGONISTS | WARNER-LAMBERT COMPANY (US) | 1998-04-29 | — | — | EP | disclosed |
| US-5654303-A | FOR TREATING NERVOUS SYSTEM OR CARDIOVASCULAR SYSTEM DISORDERS | WARNER-LAMBERT COMPANY (US) | 1997-08-05 | — | — | US | disclosed |
| WO-1996040651-A1 | ALKYL AMINE DERIVATIVES OF SUBSTITUTED QUINOXALINE 2,3-DIONES AS GLUTAMATE RECEPTOR ANTAGONISTS | WARNER-LAMBERT COMPANY (US) | 1996-12-19 | — | — | WO | disclosed |