Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3744928 | 0.90 | LIPE (0.65) | LIPE | |
| SCHEMBL744442 | 0.88 | LIPE (0.62) | LIPE | |
| SCHEMBL747135 | 0.83 | LIPE (0.64) | LIPE | |
| SCHEMBL746965 | 0.82 | LIPE (0.62) | LIPE | |
| SCHEMBL744562 | 0.81 | LIPE (0.69) | LIPE | |
| SCHEMBL745817 | 0.81 | LIPE (0.58) | LIPE | |
| SCHEMBL744233 | 0.80 | LIPE (0.55) | LIPE | |
| SCHEMBL746001 | 0.80 | LIPE (0.74) | LIPEMETAP2 | |
| SCHEMBL1589353 | 0.80 | LIPE (0.80) | LIPE | |
| SCHEMBL1589383 | 0.80 | LIPE (0.64) | LIPEMETAP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8329904-B2 | Azacyclic derivatives | HOFFMANN-LA ROCHE INC. (US) | 2012-12-11 | — | — | US | disclosed |
| US-8329904-B2 | Azacyclic derivatives | HOFFMANN-LA ROCHE INC. (US) | 2012-12-11 | — | — | US | disclosed |
| EP-2430023-A1 | AZACYCLIC SPIRODERIVATIVES AS HSL INHIBITORS | F. Hoffmann-La Roche AG (CH) | 2012-03-21 | — | — | EP | disclosed |
| WO-2010130665-A1 | AZACYCLIC SPIRODERIVATIVES AS HSL INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2010-11-18 | — | — | WO | disclosed |