SCHEMBL7464201

SCHEMBL7464201

CN1C(=O)SC(=Cc2ccccc2)C1=O

nearest known ligand 0.71

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CISD1 Q9NZ45 5/20 0.71
MAOB P27338 3/20 0.71
MAOA P21397 3/20 0.71
TDP1 Q9NUW8 2/20 0.52
AURKA O14965 1/20 0.52
LMNA P02545 1/20 0.52
KDM4E B2RXH2 1/20 0.51
CYP1A2 P05177 1/20 0.51
CYP3A4 P08684 1/20 0.51
CYP2D6 P10635 1/20 0.51
CYP2C9 P11712 1/20 0.51
CYP2C19 P33261 1/20 0.51
HTT P42858 1/20 0.51
MGAM O43451 1/20 0.51
CA12 O43570 1/20 0.51
CA1 P00915 1/20 0.51
CA2 P00918 1/20 0.51
CA9 Q16790 1/20 0.51
NPC1 O15118 1/20 0.51
CASP3 P42574 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11321794 1.00 CISD1 (0.71) CISD1MAOBMAOATDP1AURKA
SCHEMBL8388794 1.00 CISD1 (0.71) CISD1MAOBMAOATDP1AURKA
SCHEMBL12177689 0.90 AKR1B1 (0.60) CISD1MAOBMAOATDP1AURKA
SCHEMBL17934346 0.83 PIM1 (0.53) CISD1MAOBMAOATDP1MGAM
SCHEMBL11778921 0.83 CISD1 (1.00) CISD1MAOBMAOALMNARAB9A
SCHEMBL12333891 0.83 CISD1 (1.00) CISD1MAOBMAOALMNARAB9A
SCHEMBL10801539 0.83 CISD1 (1.00) CISD1MAOBMAOALMNARAB9A
SCHEMBL17934519 0.80 MYC (0.63) CISD1MAOBAURKANPC1CASP3
SCHEMBL12177140 0.80 CYP1A2 (0.53) CISD1MAOBMAOATDP1KDM4E
SCHEMBL12177278 0.79 NPC1 (0.57) TDP1NPC1CASP3RAB9ASENP8

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1214305-A1 BENZYLIDENE-THIAZOLIDINEDIONES AND ANALOGUES AND THEIR USE IN THE TREATMENT OF INFLAMMATION Maxia Pharmaceuticals, Inc. (US) 2002-06-19 EP claimed
WO-2001016123-A1 BENZYLIDENE-THIAZOLIDINEDIONES AND ANALOGUES AND THEIR USE IN THE TREATMENT OF INFLAMMATION MAXIA PHARMACEUTICALS, INC. (US) 2001-03-08 WO claimed
US-4304769-A PESTICIDES EASTMAN KODAK COMPANY (US) 1981-12-08 US disclosed
US-4247627-A Photographic elements having hydrophilic colloid layers containing hydrophobic ultraviolet absorbers uniformly loaded in latex polymer particles EASTMAN KODAK COMPANY (US) 1981-01-27 US disclosed
US-4214047-A Photographic elements having hydrophilic colloid layers containing hydrophobic addenda uniformly loaded in latex polymer particles EASTMAN KODAK COMPANY (US) 1980-07-22 US disclosed
US-4203716-A Photographic elements having hydrophilic colloid layers containing hydrophobic addenda uniformly loaded in latex polymer particles EASTMAN KODAK COMPANY (US) 1980-05-20 US disclosed
US-4199363-A Processes for achieving uniform, efficient distribution of hydrophobic materials through hydrophilic colloid layers and loaded latex compositions EASTMAN KODAK COMPANY (US) 1980-04-22 US disclosed