Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CALM1 | P0DP23 | 1/20 | 0.46 |
| ▸ | TYMP | P19971 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | CTRC | Q99895 | 2/20 | 0.35 |
| ▸ | BCL2 | P10415 | 1/20 | 0.34 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.34 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.34 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5247984 | 0.79 | CALM1 (0.52) | CALM1TYMPALDH1A1MEN1KMT2A | |
| SCHEMBL15542678 | 0.78 | CALM1 (0.41) | CALM1ALDH1A1CYP3A4MAPTKDM4E | |
| SCHEMBL10323256 | 0.76 | CALM1 (0.48) | CALM1CYP3A4MAPTKDM4EMEN1 | |
| SCHEMBL27556897 | 0.74 | CALM1 (0.46) | CALM1ALDH1A1CYP3A4MAPTKDM4E | |
| SCHEMBL27949738 | 0.74 | CALM1 (0.46) | CALM1CYP3A4MAPTKDM4EHPGD | |
| SCHEMBL11523704 | 0.74 | CALM1 (0.58) | CALM1TYMPALDH1A1CYP3A4MEN1 | |
| SCHEMBL7465412 | 0.74 | CALM1 (0.41) | CALM1ALDH1A1CYP3A4MEN1KMT2A | |
| SCHEMBL2820256 | 0.72 | CALM1 (0.73) | CALM1TYMPALDH1A1CYP3A4MAPT | |
| SCHEMBL24781301 | 0.72 | CALM1 (0.44) | CALM1TYMPALDH1A1CYP3A4MEN1 | |
| SCHEMBL11712947 | 0.72 | MEN1 (0.47) | CALM1TYMPALDH1A1CYP3A4MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1140900-A4 | PYRAZOLE COMPOUNDS AND USES THEREOF | PPD DISCOVERY INC (US) | 2002-04-10 | — | — | EP | disclosed |
| EP-1140900-A2 | PYRAZOLE COMPOUNDS AND USES THEREOF | PPD DISCOVERY, INC. (US) | 2001-10-10 | — | — | EP | disclosed |
| WO-2000039083-A2 | PYRAZOLE COMPOUNDS AND USES THEREOF | PPD DISCOVERY, INC. (US) | 2000-07-06 | — | — | WO | disclosed |