Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 11/20 | 0.52 |
| ▸ | CLK4 | Q9HAZ1 | 11/20 | 0.52 |
| ▸ | CLK1 | P49759 | 8/20 | 0.52 |
| ▸ | DYRK1B | Q9Y463 | 8/20 | 0.52 |
| ▸ | CLK2 | P49760 | 7/20 | 0.52 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.48 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.48 |
| ▸ | PRKACA | P17612 | 1/20 | 0.48 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.48 |
| ▸ | AKT1 | P31749 | 1/20 | 0.48 |
| ▸ | MATK | P42679 | 1/20 | 0.48 |
| ▸ | GSK3A | P49840 | 1/20 | 0.48 |
| ▸ | GSK3B | P49841 | 1/20 | 0.48 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.48 |
| ▸ | NEK4 | P51957 | 1/20 | 0.48 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.48 |
| ▸ | PRKG1 | Q13976 | 1/20 | 0.48 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.48 |
| ▸ | CDC42BPA | Q5VT25 | 1/20 | 0.48 |
| ▸ | HIPK4 | Q8NE63 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7467627 | 0.78 | ABL1 (0.61) | DYRK1ACLK4CLK1DYRK1BCLK2 | |
| SCHEMBL4154191 | 0.74 | IKBKB (0.55) | — | |
| SCHEMBL4906864 | 0.73 | MKNK1 (0.71) | MKNK1HIF1AMKNK2 | |
| SCHEMBL7466961 | 0.71 | SRC (0.63) | ABL1BCRSRC | |
| SCHEMBL10917879 | 0.71 | ABL1 (0.51) | DYRK1AROCK1AURKBABL1BCR | |
| SCHEMBL7471338 | 0.71 | MKNK1 (0.51) | DYRK1BROCK2ROCK1PKN2MKNK1 | |
| SCHEMBL3654446 | 0.70 | DYRK1A (0.52) | DYRK1ACLK4CLK1DYRK1BCLK2 | |
| SCHEMBL30299573 | 0.70 | DYRK1A (0.55) | DYRK1ACLK4CLK1DYRK1BCLK2 | |
| SCHEMBL7465536 | 0.69 | ABL1 (0.54) | ABL1BCRSRC | |
| SCHEMBL2580846 | 0.69 | ABL1 (0.74) | PRKACAABL1BCRSRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0233461-B2 | 4,5,6-Substituted-2-pyrimidinamines | AMERICAN CYANAMID CO (US) | 2002-05-29 | — | — | EP | disclosed |