Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | HPGD | P15428 | 1/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.55 |
| ▸ | UTS2R | Q9UKP6 | 3/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | CCNC | P24863 | 1/20 | 0.44 |
| ▸ | CDK8 | P49336 | 1/20 | 0.44 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.40 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.40 |
| ▸ | APP | P05067 | 1/20 | 0.38 |
| ▸ | LATS1 | O95835 | 3/20 | 0.38 |
| ▸ | LATS2 | Q9NRM7 | 2/20 | 0.38 |
| ▸ | PDE5A | O76074 | 2/20 | 0.38 |
| ▸ | SYK | P43405 | 1/20 | 0.37 |
| ▸ | FDPS | P14324 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7479010 | 0.89 | TLR8 (0.51) | ALDH1A1KDM4EHPGDHSD17B10UTS2R | |
| SCHEMBL11666495 | 0.88 | UTS2R (0.48) | ALDH1A1KDM4EHPGDHSD17B10UTS2R | |
| SCHEMBL7468377 | 0.85 | GRM5 (0.43) | ALDH1A1KDM4EHPGDHSD17B10UTS2R | |
| SCHEMBL29882733 | 0.81 | KDM4E (0.47) | ALDH1A1KDM4EHPGDHSD17B10HTT | |
| SCHEMBL18356238 | 0.81 | KDM4E (0.47) | ALDH1A1KDM4EHPGDHSD17B10HTT | |
| SCHEMBL13931357 | 0.81 | SYK (0.46) | ALDH1A1KDM4EHPGDHSD17B10SYK | |
| SCHEMBL7470851 | 0.81 | CYP2C19 (0.54) | SYK | |
| SCHEMBL1255125 | 0.81 | UTS2R (0.48) | ALDH1A1KDM4EHSD17B10UTS2RHTT | |
| SCHEMBL6442879 | 0.79 | KDM4E (0.57) | ALDH1A1KDM4EHPGDHSD17B10UTS2R | |
| SCHEMBL1977303 | 0.79 | KDM4E (0.57) | ALDH1A1KDM4EHPGDHSD17B10UTS2R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022086920-A1 | GLUTAMINYL-PEPTIDE CYCLOTRANSFERASE LIKE (QPCTL) PROTEIN INHIBITORS AND USES THEREOF | BLACKSMITH MEDICINES, INC. (US) | 2022-04-28 | — | — | WO | disclosed |
| EP-0963986-B1 | 5,10-Dihydrodipyrido(2,3-b:2,3-e)pyrazine and 5,10-dihydro(2,3-b:3,2-e)pyrazine, process for their preparation and pharmaceutical compositions containing them | SERVIER LAB (FR) | 2002-04-17 | — | — | EP | disclosed |
| US-6127369-A | 5,10-dihydrodipyrido[2,3-b:2,3-e]pyrazin and 5,10-dihydrodipyrido[2,3-b:3,2-e]pyrazin compounds | ADIR ET COMPAGNIE (FR) | 2000-10-03 | — | — | US | disclosed |
| EP-0963986-A2 | 5,10-Dihydrodipyrido(2,3-b:2,3-e)pyrazine and 5,10-dihydro(2,3-b:3,2-e)pyrazine, process for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1999-12-15 | — | — | EP | disclosed |