Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 5/20 | 0.51 |
| ▸ | TLR7 | Q9NYK1 | 3/20 | 0.51 |
| ▸ | UTS2R | Q9UKP6 | 6/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | FLT3 | P36888 | 3/20 | 0.41 |
| ▸ | TYRO3 | Q06418 | 3/20 | 0.41 |
| ▸ | MERTK | Q12866 | 3/20 | 0.41 |
| ▸ | GAS6 | Q14393 | 3/20 | 0.41 |
| ▸ | AXL | P30530 | 2/20 | 0.41 |
| ▸ | SYK | P43405 | 1/20 | 0.41 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11666495 | 0.95 | UTS2R (0.48) | TLR8TLR7UTS2RCYP3A4CYP2D6 | |
| SCHEMBL7464659 | 0.89 | ALDH1A1 (0.55) | TLR8TLR7UTS2RCYP3A4CYP2D6 | |
| SCHEMBL7468377 | 0.82 | GRM5 (0.43) | UTS2RCYP3A4CYP2D6NPC1KDM4E | |
| SCHEMBL26686723 | 0.81 | KDM4E (0.46) | KDM4EALDH1A1HPGDHSD17B10FLT3 | |
| SCHEMBL31420488 | 0.81 | KDM4E (0.46) | KDM4EALDH1A1HPGDHSD17B10FLT3 | |
| SCHEMBL6439936 | 0.81 | TLR8 (0.52) | TLR8TLR7UTS2RCYP3A4CYP2D6 | |
| SCHEMBL18356238 | 0.79 | KDM4E (0.47) | CYP3A4KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL29882733 | 0.79 | KDM4E (0.47) | CYP3A4KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL13931357 | 0.79 | SYK (0.46) | CYP2D6NPC1KDM4EALDH1A1HPGD | |
| SCHEMBL1255125 | 0.78 | UTS2R (0.48) | TLR7UTS2RCYP3A4NPC1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0963986-B1 | 5,10-Dihydrodipyrido(2,3-b:2,3-e)pyrazine and 5,10-dihydro(2,3-b:3,2-e)pyrazine, process for their preparation and pharmaceutical compositions containing them | SERVIER LAB (FR) | 2002-04-17 | — | — | EP | disclosed |
| US-6127369-A | 5,10-dihydrodipyrido[2,3-b:2,3-e]pyrazin and 5,10-dihydrodipyrido[2,3-b:3,2-e]pyrazin compounds | ADIR ET COMPAGNIE (FR) | 2000-10-03 | — | — | US | disclosed |
| EP-0963986-A2 | 5,10-Dihydrodipyrido(2,3-b:2,3-e)pyrazine and 5,10-dihydro(2,3-b:3,2-e)pyrazine, process for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1999-12-15 | — | — | EP | disclosed |