Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 11/20 | 0.79 |
| ▸ | BCR | P11274 | 9/20 | 0.79 |
| ▸ | PRKCA | P17252 | 8/20 | 0.79 |
| ▸ | PRKCD | Q05655 | 5/20 | 0.79 |
| ▸ | SRC | P12931 | 5/20 | 0.79 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.79 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.79 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.67 |
| ▸ | EGFR | P00533 | 4/20 | 0.66 |
| ▸ | IKBKB | O14920 | 1/20 | 0.58 |
| ▸ | PRKACA | P17612 | 1/20 | 0.55 |
| ▸ | PRKACG | P22612 | 1/20 | 0.55 |
| ▸ | PRKACB | P22694 | 1/20 | 0.55 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.55 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.52 |
| ▸ | PRKCG | P05129 | 1/20 | 0.52 |
| ▸ | PRKCB | P05771 | 1/20 | 0.52 |
| ▸ | LCK | P06239 | 1/20 | 0.52 |
| ▸ | PRKCH | P24723 | 1/20 | 0.52 |
| ▸ | PRKCI | P41743 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6256104 | 0.89 | ABL1 (1.00) | ABL1BCRPRKCAPRKCDSRC | |
| SCHEMBL7462511 | 0.86 | IKBKB (0.64) | ABL1BCRPRKCAPRKCDSRC | |
| SCHEMBL14319833 | 0.84 | ABL1 (0.60) | ABL1BCRPRKCAPRKCDSRC | |
| SCHEMBL4902560 | 0.83 | ABL1 (0.72) | ABL1BCRPRKCAPRKCDSRC | |
| SCHEMBL4903199 | 0.83 | IKBKB (0.64) | ABL1BCRPRKCAPRKCDSRC | |
| SCHEMBL7535971 | 0.81 | ABL1 (0.55) | ABL1BCRPRKCAPRKCDSRC | |
| SCHEMBL21526357 | 0.81 | ACVR1 (1.00) | ACVR1 | |
| SCHEMBL3756287 | 0.81 | MAPK8 (0.69) | ABL1BCRPRKCAPRKCDSRC | |
| SCHEMBL4899264 | 0.81 | JAK2 (0.66) | ABL1BCRPRKCAPRKCDSRC | |
| SCHEMBL6262145 | 0.80 | ABL1 (1.00) | ABL1BCRPRKCAPRKCDSRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0233461-B2 | 4,5,6-Substituted-2-pyrimidinamines | AMERICAN CYANAMID CO (US) | 2002-05-29 | — | — | EP | claimed |
| EP-0233461-B1 | 4,5,6-Substituted-2-pyrimidinamines | AMERICAN CYANAMID CO (US) | 1996-03-20 | — | — | EP | claimed |
| US-4788195-A | TREATING ASTHMA, ALLERGIC DISEASES, INFLAMMATION AND DIABETES IN MAMMALS | AMERICAN CYANAMID COMPANY (US) | 1988-11-29 | — | — | US | claimed |
| EP-0233461-A2 | 4,5,6-Substituted-2-pyrimidinamines | AMERICAN CYANAMID COMPANY (US) | 1987-08-26 | — | — | EP | claimed |
| EP-0233461-B2 | 4,5,6-Substituted-2-pyrimidinamines | AMERICAN CYANAMID CO (US) | 2002-05-29 | — | — | EP | disclosed |