Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 5/20 | 0.38 |
| ▸ | CA2 | P00918 | 4/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.37 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.37 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.35 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.34 |
| ▸ | JAK1 | P23458 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7464844 | 1.00 | CA12 (0.38) | CA12CA2OPRM1OPRK1ENPP1 | |
| SCHEMBL8108159 | 0.83 | SLC6A4 (0.44) | OPRM1LMNASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL8108155 | 0.83 | SLC6A4 (0.44) | OPRM1LMNASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL14081576 | 0.78 | SLC6A2 (0.46) | CHRM1LMNASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL5829818 | 0.78 | SLC6A2 (0.55) | CA12ENPP1BRD4CREBBPSLC6A2 | |
| SCHEMBL7458682 | 0.73 | CHRM1 (0.44) | OPRM1OPRK1CHRM1SLC6A4 | |
| SCHEMBL2071511 | 0.73 | TSHR (0.42) | LMNANPSR1MAPTPOLBHTT | |
| SCHEMBL2071513 | 0.73 | TSHR (0.42) | LMNANPSR1MAPTPOLBHTT | |
| SCHEMBL6775690 | 0.69 | HDAC3 (0.41) | CA2CHRM1LMNANPSR1MAPT | |
| SCHEMBL6775687 | 0.69 | HDAC3 (0.41) | CA2CHRM1LMNANPSR1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1242419-A1 | AZABICYCLO 3.2.1]OCTANE DERIVATIVES | ELI LILLY AND COMPANY (US) | 2002-09-25 | — | — | EP | disclosed |
| WO-2001046187-A1 | AZABICYCLO[3.2.1]OCTANE DERIVATIVES | ELI LILLY AND COMPANY (US) | 2001-06-28 | — | — | WO | disclosed |