SCHEMBL7464893

SCHEMBL7464893

Cc1ccc(Oc2ccnc3c(Cl)cccc23)cc1

nearest known ligand 0.47

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
NR4A2 P43354 1/20 0.47
CCNC P24863 4/20 0.44
CDK8 P49336 4/20 0.44
SMN1; SMN2 Q16637 2/20 0.44
ALDH1A1 P00352 2/20 0.44
KDM4E B2RXH2 1/20 0.44
HTT P42858 1/20 0.42
HSD17B10 Q99714 1/20 0.42
NR1H2 P55055 1/20 0.41
NR1H3 Q13133 1/20 0.41
KDR P35968 3/20 0.40
PDGFRA P16234 2/20 0.39
MAPT P10636 1/20 0.39
RECQL P46063 1/20 0.39
L3MBTL1 Q9Y468 1/20 0.39
MEN1 O00255 1/20 0.38
KMT2A Q03164 1/20 0.38
PTGDR2 Q9Y5Y4 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7459668 0.88 NR4A2 (0.47) NR4A2CCNCCDK8SMN1; SMN2ALDH1A1
SCHEMBL7468059 0.87 NR4A2 (0.46) NR4A2CCNCCDK8SMN1; SMN2ALDH1A1
SCHEMBL7459544 0.86 NR1H2 (0.47) NR4A2SMN1; SMN2ALDH1A1KDM4EHTT
SCHEMBL7467027 0.86 NR4A2 (0.45) NR4A2CCNCCDK8SMN1; SMN2ALDH1A1
SCHEMBL7468079 0.86 FGFR2 (0.47) NR4A2CCNCCDK8SMN1; SMN2ALDH1A1
SCHEMBL7468223 0.85 NR4A2 (0.47) NR4A2CCNCCDK8SMN1; SMN2ALDH1A1
SCHEMBL7461771 0.85 NR4A2 (0.44) NR4A2CCNCCDK8SMN1; SMN2ALDH1A1
SCHEMBL7466493 0.85 NR4A2 (0.44) NR4A2CCNCCDK8SMN1; SMN2ALDH1A1
SCHEMBL7531657 0.84 NR4A2 (0.59) NR4A2CCNCCDK8SMN1; SMN2ALDH1A1
SCHEMBL7460036 0.83 KDM4E (0.46) NR4A2CCNCCDK8SMN1; SMN2ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0326330-B1 Quinoline fungicides DOW AGROSCIENCES LLC (US) 2002-07-24 EP claimed
US-5145843-A For plants DOWELANCO (US) 1992-09-08 US claimed
EP-0326330-B1 Quinoline fungicides DOW AGROSCIENCES LLC (US) 2002-07-24 EP disclosed
US-5145843-A For plants DOWELANCO (US) 1992-09-08 US disclosed