Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | PRKCQ | Q04759 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | GFER | P55789 | 1/20 | 0.43 |
| ▸ | PIM2 | Q9P1W9 | 2/20 | 0.42 |
| ▸ | PRKCA | P17252 | 1/20 | 0.42 |
| ▸ | GSK3B | P49841 | 1/20 | 0.42 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.38 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.38 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2260505 | 0.88 | NPC1 (0.68) | NPC1GAAMEN1KMT2AUSP2 | |
| SCHEMBL29683649 | 0.85 | KDM4E (0.48) | NPC1MEN1KMT2AHTTTSHR | |
| SCHEMBL27701838 | 0.83 | NPC1 (0.45) | NPC1GAAMEN1KMT2AUSP2 | |
| SCHEMBL3961543 | 0.82 | NPC1 (0.72) | NPC1GAAMEN1KMT2AUSP2 | |
| SCHEMBL28086833 | 0.80 | NPC1 (0.70) | NPC1GAAMEN1KMT2AUSP2 | |
| SCHEMBL7823573 | 0.79 | NPC1 (0.46) | NPC1GAAMEN1KMT2AUSP2 | |
| SCHEMBL28989190 | 0.78 | NPC1 (0.48) | NPC1GAAMEN1KMT2AUSP2 | |
| SCHEMBL5540639 | 0.77 | GAA (0.51) | NPC1GAAMEN1KMT2AUSP2 | |
| SCHEMBL5540633 | 0.77 | MEN1 (0.49) | NPC1GAAMEN1KMT2AUSP2 | |
| SCHEMBL27676401 | 0.76 | ALDH1A1 (0.48) | NPC1GAASMN1; SMN2NOTUMTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1229025-A1 | NOVEL QUINAZOLINE DERIVATIVES | Japan Energy Corporation (JP) | 2002-08-07 | — | — | EP | disclosed |