Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CKS1B | P61024 | 1/20 | 0.45 |
| ▸ | SKP1 | P63208 | 1/20 | 0.45 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.45 |
| ▸ | BRD4 | O60885 | 5/20 | 0.37 |
| ▸ | SUV39H2 | Q9H5I1 | 2/20 | 0.37 |
| ▸ | BCHE | P06276 | 1/20 | 0.35 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.34 |
| ▸ | NR1H2 | P55055 | 4/20 | 0.34 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.34 |
| ▸ | NQO2 | P16083 | 1/20 | 0.33 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.33 |
| ▸ | PIM1 | P11309 | 1/20 | 0.33 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7481176 | 0.80 | CKS1B (0.45) | CKS1BSKP1SKP2BRD4SUV39H2 | |
| SCHEMBL7484398 | 0.77 | CKS1B (0.42) | CKS1BSKP1SKP2BRD4SUV39H2 | |
| SCHEMBL7459831 | 0.74 | AAK1 (0.38) | NR1H2 | |
| SCHEMBL7023036 | 0.74 | NR1H2 (0.39) | BCHENR1H2 | |
| SCHEMBL18764825 | 0.66 | ALDH1A1 (0.53) | BRD4BCHENR1H2 | |
| SCHEMBL837529 | 0.65 | CKS1B (0.64) | CKS1BSKP1SKP2SUV39H2BCHE | |
| SCHEMBL16791380 | 0.65 | CKS1B (0.57) | CKS1BSKP1SKP2BRD4SUV39H2 | |
| SCHEMBL16791381 | 0.65 | CKS1B (0.57) | CKS1BSKP1SKP2SUV39H2BCHE | |
| SCHEMBL17858035 | 0.65 | CKS1B (0.51) | CKS1BSKP1SKP2SUV39H2BCHE | |
| SCHEMBL2341656 | 0.63 | MAPT (0.51) | BRD4BCHEMAP4K1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6495542-B1 | SUCH AS 2-METHOXY-N-(2-METHYL-1H-BENZIMIDAZOL-4-YL)-4-(2,3,4,5-TETRAHYDRO-5-OXO-1H-1-BENZAZEPIN-1-YL)CARBONYL-BENZAM IDE; HYPERTENSION, HEART FAILURE, RENAL INSUFFICIENCY, EDEMA, ASCITES, VASOPRESSIN PARASECRETION SYNDROME | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2002-12-17 | — | — | US | disclosed |