Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 10/20 | 0.65 |
| ▸ | ADORA2A | P29274 | 10/20 | 0.65 |
| ▸ | PDE4B | Q07343 | 10/20 | 0.65 |
| ▸ | PDE4C | Q08493 | 10/20 | 0.65 |
| ▸ | PDE4D | Q08499 | 10/20 | 0.65 |
| ▸ | ADORA2B | P29275 | 11/20 | 0.58 |
| ▸ | CHIT1 | Q13231 | 1/20 | 0.57 |
| ▸ | CHIA | Q9BZP6 | 1/20 | 0.57 |
| ▸ | ADORA3 | P0DMS8 | 4/20 | 0.55 |
| ▸ | CFTR | P13569 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7459580 | 0.99 | PDE4A (0.66) | PDE4AADORA2APDE4BPDE4CPDE4D | |
| SCHEMBL7459399 | 0.95 | PDE4A (0.67) | PDE4AADORA2APDE4BPDE4CPDE4D | |
| SCHEMBL7454848 | 0.89 | ADORA2B (0.67) | PDE4AADORA2APDE4BPDE4CPDE4D | |
| SCHEMBL8658762 | 0.88 | PDE4A (0.61) | PDE4AADORA2APDE4BPDE4CPDE4D | |
| SCHEMBL8660134 | 0.87 | PDE4A (0.62) | PDE4AADORA2APDE4BPDE4CPDE4D | |
| SCHEMBL8660052 | 0.86 | PDE4A (0.63) | PDE4AADORA2APDE4BPDE4CPDE4D | |
| SCHEMBL7465209 | 0.82 | PDE4A (0.68) | PDE4AADORA2APDE4BPDE4CPDE4D | |
| SCHEMBL7458212 | 0.82 | PDE4A (0.89) | PDE4AADORA2APDE4BPDE4CPDE4D | |
| SCHEMBL8656750 | 0.81 | PDE4A (0.87) | PDE4AADORA2APDE4BPDE4CPDE4D | |
| SCHEMBL21381258 | 0.81 | PDE4A (0.92) | PDE4AADORA2APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0771813-B1 | Alkylxanthine phosphonates and alkylxanthine phosphine oxydes and their use as medicines | HOECHST AG (DE) | 2002-01-16 | — | — | EP | disclosed |
| EP-0771813-A1 | Alkylxanthine phosphonates and alkylxanthine phosphine oxydes and their use as medicines | HOECHST AKTIENGESELLSCHAFT (DE) | 1997-05-07 | — | — | EP | disclosed |