Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 11/20 | 0.58 |
| ▸ | SRC | P12931 | 3/20 | 0.57 |
| ▸ | MAPT | P10636 | 3/20 | 0.57 |
| ▸ | ABL1 | P00519 | 2/20 | 0.57 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.57 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.57 |
| ▸ | KDR | P35968 | 2/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.57 |
| ▸ | USP2 | O75604 | 1/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.57 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.57 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.57 |
| ▸ | TSHR | P16473 | 1/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.57 |
| ▸ | RAF1 | P04049 | 1/20 | 0.55 |
| ▸ | BRAF | P15056 | 1/20 | 0.55 |
| ▸ | PDE5A | O76074 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7473037 | 0.83 | SRC (0.49) | EGFRSRCMAPTABL1PDGFRB | |
| SCHEMBL14627244 | 0.82 | RAF1 (0.64) | EGFRSRCMAPTABL1PDGFRB | |
| SCHEMBL5564677 | 0.82 | KDM4E (0.66) | EGFRSRCMAPTABL1PDGFRB | |
| SCHEMBL5565334 | 0.81 | SRC (0.71) | EGFRSRCKDRRAF1BRAF | |
| SCHEMBL5568094 | 0.81 | PDE5A (0.66) | EGFRSRCMAPTABL1PDGFRB | |
| SCHEMBL15426078 | 0.81 | PDE5A (0.66) | EGFRSRCMAPTABL1PDGFRB | |
| SCHEMBL8667642 | 0.81 | EGFR (0.66) | EGFRMAPTKDM4EUSP2CYP1A2 | |
| SCHEMBL7471052 | 0.79 | PDE5A (0.82) | PDE5AMEN1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL7473882 | 0.78 | EGFR (0.68) | EGFRMAPTPDGFRBKDRUSP2 | |
| SCHEMBL7467527 | 0.77 | PDE5A (0.64) | PDE5AMEN1KMT2AALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1229025-A1 | NOVEL QUINAZOLINE DERIVATIVES | Japan Energy Corporation (JP) | 2002-08-07 | — | — | EP | disclosed |