SCHEMBL7465311

SCHEMBL7465311

C[SiH](C)OC(CC1Oc2c(Cl)cc(Cl)cc2NC1=O)C(C)(C)C

nearest known ligand 0.32

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
HSD17B10 Q99714 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7463472 0.83 HSD17B10 (0.48) HSD17B10
SCHEMBL7465292 0.76
SCHEMBL7472425 0.75 PARP1 (0.45) HSD17B10
SCHEMBL7468831 0.75 USP2 (0.42) HSD17B10
SCHEMBL7470594 0.75 USP2 (0.53) HSD17B10
SCHEMBL8601457 0.74 USP2 (0.39) HSD17B10
SCHEMBL7468492 0.74 BRD4 (0.39)
SCHEMBL7475258 0.73 HSD17B10 (0.44) HSD17B10
SCHEMBL7478473 0.73 KMT2A (0.42) HSD17B10
SCHEMBL7464320 0.72 USP2 (0.38) HSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0869949-B1 BENZOXAZINE ANTIMICROBIAL AGENTS ORTHO MCNEIL PHARM INC (US) 2002-12-18 EP disclosed
US-5854242-A Benzoxazine antimicrobial agents ORTHO PHARMACEUTICAL CORPORATION (US) 1998-12-29 US disclosed
US-5696117-A BACTERICIDE ORTHO PHARMACEUTICAL CORPORATION (US) 1997-12-09 US disclosed