Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 4/20 | 0.56 |
| ▸ | CCND3 | P30281 | 4/20 | 0.56 |
| ▸ | GSK3B | P49841 | 4/20 | 0.56 |
| ▸ | PIM1 | P11309 | 3/20 | 0.56 |
| ▸ | CCNA2 | P20248 | 9/20 | 0.56 |
| ▸ | CDK2 | P24941 | 9/20 | 0.56 |
| ▸ | CCNA1 | P78396 | 9/20 | 0.56 |
| ▸ | MTOR | P42345 | 2/20 | 0.54 |
| ▸ | ABL1 | P00519 | 3/20 | 0.51 |
| ▸ | BCR | P11274 | 3/20 | 0.51 |
| ▸ | PRKCA | P17252 | 2/20 | 0.51 |
| ▸ | SRC | P12931 | 2/20 | 0.51 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.51 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.51 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.51 |
| ▸ | IKBKB | O14920 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7535607 | 0.85 | SYK (0.54) | CDK4CCND3GSK3BPIM1CCNA2 | |
| SCHEMBL25068502 | 0.81 | CDK4 (0.85) | CDK4CCND3GSK3BPIM1CCNA2 | |
| SCHEMBL7462511 | 0.78 | IKBKB (0.64) | ABL1BCRPRKCASRCPDGFRB | |
| SCHEMBL7463426 | 0.78 | ABL1 (0.80) | ABL1BCRPRKCASRCPDGFRB | |
| SCHEMBL4902560 | 0.73 | ABL1 (0.72) | GSK3BABL1BCRPRKCASRC | |
| SCHEMBL3536285 | 0.72 | ABL1 (0.76) | ABL1BCRPRKCASRCPDGFRB | |
| SCHEMBL4901590 | 0.72 | ABL1 (0.67) | CDK4GSK3BCDK2MTORABL1 | |
| SCHEMBL25068536 | 0.72 | CDK4 (1.00) | CDK4CCND3GSK3BPIM1CCNA2 | |
| SCHEMBL16941489 | 0.71 | ABL1 (0.61) | GSK3BCDK2ABL1BCRPRKCA | |
| SCHEMBL25068498 | 0.71 | CCNA2 (0.85) | CDK4CCND3GSK3BPIM1CCNA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0233461-B2 | 4,5,6-Substituted-2-pyrimidinamines | AMERICAN CYANAMID CO (US) | 2002-05-29 | — | — | EP | disclosed |