Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 10/20 | 0.54 |
| ▸ | CDK4 | P11802 | 2/20 | 0.52 |
| ▸ | CCND3 | P30281 | 2/20 | 0.52 |
| ▸ | GSK3B | P49841 | 2/20 | 0.52 |
| ▸ | PIM1 | P11309 | 1/20 | 0.52 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.50 |
| ▸ | CDK2 | P24941 | 3/20 | 0.50 |
| ▸ | CCNA1 | P78396 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7465702 | 0.85 | CDK4 (0.56) | CDK4CCND3GSK3BPIM1CCNA2 | |
| SCHEMBL7465915 | 0.80 | ABL1 (0.71) | SYKABL1PDGFRBBCRSRC | |
| SCHEMBL7535971 | 0.79 | ABL1 (0.55) | SYKCYP3A4ABL1PDGFRBBCR | |
| SCHEMBL5732656 | 0.73 | AURKA (0.66) | SYKCDK4GSK3BCDK2ABL1 | |
| SCHEMBL14651222 | 0.70 | SYK (0.71) | SYK | |
| SCHEMBL14651219 | 0.70 | SYK (0.67) | SYK | |
| SCHEMBL7464407 | 0.70 | SYK (0.59) | SYKCDK4CDK2MEN1LMNA | |
| SCHEMBL14651461 | 0.69 | SYK (0.72) | SYKABL1BCRPRKCA | |
| SCHEMBL7535601 | 0.69 | CYP1A2 (0.46) | MEN1ALDH1A1LMNACYP1A2CYP3A4 | |
| SCHEMBL7469928 | 0.69 | ABL1 (0.64) | SYKCDK4GSK3BPIM1CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0233461-B2 | 4,5,6-Substituted-2-pyrimidinamines | AMERICAN CYANAMID CO (US) | 2002-05-29 | — | — | EP | disclosed |