Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| A-192621 SCHEMBL1030269 | 1.00 | EDNRB (1.00) | EDNRBEDNRA | |
| A-192621 SCHEMBL29551251 | 1.00 | EDNRB (1.00) | EDNRBEDNRA | |
| A-192621 SCHEMBL3982388 | 1.00 | EDNRB (1.00) | EDNRBEDNRA | |
| A-192621 SCHEMBL22404939 | 1.00 | EDNRB (1.00) | EDNRBEDNRA | |
| A-192621 SCHEMBL3982386 | 1.00 | EDNRB (1.00) | EDNRBEDNRA | |
| SCHEMBL8176298 | 0.97 | EDNRB (0.94) | EDNRBEDNRA | |
| SCHEMBL8189498 | 0.94 | EDNRB (1.00) | EDNRBEDNRA | |
| SCHEMBL8189503 | 0.94 | EDNRB (1.00) | EDNRBEDNRA | |
| SCHEMBL8185019 | 0.94 | EDNRB (1.00) | EDNRBEDNRA | |
| SCHEMBL8180058 | 0.94 | EDNRB (1.00) | EDNRBEDNRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0888340-B1 | 4-(BENZO-1,3-DIOXOLYL)-PYRROLIDINE-3-CARBOXYLIC ACID DERIVATIVES AS ENDOTHELIN ANTAGONISTS | ABBOTT LAB (US) | 2002-07-17 | — | — | EP | claimed |
| US-6124341-A | A DRUG FOR TREATING HYPERTENSION, CONGESTIVE HEART FAILURE, RESTENOSIS FOLLOWING ARTERIAL INJURY, CEREBRAL OR MYOCARDIAL ISCHEMIA OR ATHEROSCLEROSIS; VASODILUTOR | ABBOTT LABORATORIES (US) | 2000-09-26 | — | — | US | claimed |
| EP-0888340-B1 | 4-(BENZO-1,3-DIOXOLYL)-PYRROLIDINE-3-CARBOXYLIC ACID DERIVATIVES AS ENDOTHELIN ANTAGONISTS | ABBOTT LAB (US) | 2002-07-17 | — | — | EP | disclosed |
| US-6124341-A | A DRUG FOR TREATING HYPERTENSION, CONGESTIVE HEART FAILURE, RESTENOSIS FOLLOWING ARTERIAL INJURY, CEREBRAL OR MYOCARDIAL ISCHEMIA OR ATHEROSCLEROSIS; VASODILUTOR | ABBOTT LABORATORIES (US) | 2000-09-26 | — | — | US | disclosed |
| EP-0991620-A1 | PYRROLIDINE CARBOXYLIC ACID DERIVATIVES AS ENDOTHELIN ANTAGONISTS | Abbott Laboratories (US) | 2000-04-12 | — | — | EP | disclosed |
| EP-0888340-A1 | 4-(BENZO-1,3-DIOXOLYL)-PYRROLIDINE-3-CARBOXYLIC ACID DERIVATIVES AS ENDOTHELIN ANTAGONISTS | Abbott Laboratories (US) | 1999-01-07 | — | — | EP | disclosed |
| WO-1998057933-A1 | PYRROLIDINE CARBOXYLIC ACID DERIVATIVES AS ENDOTHELIN ANTAGONISTS | ABBOTT LABORATORIES (US) | 1998-12-23 | — | — | WO | disclosed |
| WO-1997030046-A1 | 4-(BENZO-1,3-DIOXOLYL)-PYRROLIDINE-3-CARBOXYLIC ACID DERIVATIVES AS ENDOTHELIN ANTAGONISTS | ABBOTT LABORATORIES (US) | 1997-08-21 | — | — | WO | disclosed |